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|Title:||Alkanolamine derivatives for treating hypertension|
|Abstract:||1-(ELECTRONEGATIVELY-SUBSTITUTED-ALKYL- OR ALKENYLPHENOXY)-3-ALKYLAMINO-2-PROPANOL DERIVATIVES, FOR EXAMPLE 1-P-CARBAMOYLMETHYLPHENOXY-3-ISOPROPYLAMINO-2-PROPANOL, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM POSSESS .beta.-ADRENERGIC BLOCKING ACTIVITY AND ARE USEFUL IN THE TREATMENT OF HEART DISEASES AND OTHER COMPLAINTS IN MAN.|
|Inventor(s):||Barrett; Arthur Michael (Leeds, EN), Carter; John (Macclesfield, EN), Hull; Roy (Macclesfield, EN), Le Count; David James (Macclesfield, EN), Squire; Christopher John (Macclesfield, EN)|
|Assignee:||Imperial Chemical Industries Limited (London, EN)|
1. A method for the treatment of hypertension in a warm-blooded animal in need of such treatment which comprises administering orally, parenterally or by inhalation to said
animal an effective amount of at least one alkanolamine derivative selected from the group consisting of a compound of the formula: ##SPC7##
wherein R.sup.1 is isopropyl or t-butyl, R.sup.2 is carbamoyl or alkylcarbamoyl of up to 4 carbon atoms, A is alkylene of 1 to 5 carbon atoms or alkenylene of 2 to 5 carbon atoms and R.sup.3 is hydrogen, halogen or alkyl, alkenyl or alkoxy each of up to 4 carbon atoms; and a non-toxic, pharmaceutically acceptable acid-addition salt thereof.
2. The method of claim 1 wherein the alkanolamine derivative is 1-p-carbamoylmethylphenoxy-3-isopropylamino-2-propanol or a non-toxic, pharmaceutically acceptable acid-addition salt thereof.
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