You’re using a public version of DrugPatentWatch with 5 free searches available | Register to unlock more free searches. CREATE FREE ACCOUNT

Last Updated: March 28, 2024

Claims for Patent: 3,928,598


✉ Email this page to a colleague

« Back to Dashboard


Summary for Patent: 3,928,598
Title: Hexahydro-dibenzo[b,d]pyran-9-ones as an anti-anxiety drug
Abstract:Use of 1-hydroxy-3-alkyl-6,6a,7,8,10,10a-hexahydro-9H-dibenzo[b,d]pyran-9-ones as psychotropic drugs, particularly as anti-anxiety and/or anti-depressant drugs, as sedative and/or analgesic drugs, and pharmaceutical compositions containing same.
Inventor(s): Archer; Robert A. (Indianapolis, IN)
Assignee: Eli Lilly and Company (Indianapolis, IN)
Application Number:05/413,009
Patent Claims: 1. A process for treating mammals suffering for anxiety which comprises administering to a mammal in need of such treatment a dose of a compound represented by the formula ##SPC6##

wherein R' is either C.sub.7 -C.sub.10 normal alkyl or is the group ##EQU3## wherein R" is C.sub.2 -C.sub.7 alkyl and R.sup.v is H or methyl, wherein both R groups are identical and are H or methyl and wherein R'" is H or C.sub.1 -C.sub.4 alkanoyl, in an amount effective to treat anxiety.

2. A process according to claim 1 in which a dose of from 0.1 to 100 mgs per day of the drug is administered.

3. A process according to claim 1 in which a dose of from 1 to 20 mgs. per day of the drug is administered.

4. A process according to claim 1 in which the drug is administered by the oral route.

5. A process according to claim 1 in which dl-trans-1-hydroxy-3-(1',1'-dimethylheptyl)-6,6a.beta.,7,8,10,10a.alpha.-h exahydro-6,6-dimethyl-9H-dibenzo[b,d]pyran-9-one is administered.

6. A process according to claim 1 in which dl-trans-1-hydroxy-3-(1',2'-dimethylheptyl)-6,6a.beta.,7,8,10,10a.alpha.-h exahydro-6,6-dimethyl-9H-dibenzo[b,d]pyran-9-one is administered.

7. A process according to claim 1 in which dl-trans-1-hydroxy-3-(1'-methylheptyl)-6,6a.beta.,7,8,10,10a.alpha.-hexahy dro-6,6-dimethyl-9H-dibenzo[b,d]pyran-9-one is administered.

8. A pharmaceutical composition, in unit dosage form, for the treatment of anxiety, consisting of a pharmaceutical carrier and, as a therapeutic agent, from 0.1 to 25 mg. of a compound of the formula ##SPC7##

wherein R' is either C.sub.7 -C.sub.10 normal alkyl or is ##EQU4## wherein R" is C.sub.2 -C.sub.7 alkyl and R.sup.v is H or methyl, wherein both R groups are identical and are H or methyl and wherein R'" is H or C.sub.1 -C.sub.4 alkanoyl, effective to treat anxiety.

9. A pharamceutical composition according to claim 8 in which dl-trans-1-hydroxy-3-(1',1'-dimethylheptyl)-6,6a.beta.,7,8,10,10a.alpha.-h exahydro-,6,6-dimethyl-9H-dibenzo[b,d]pyran9-one is the therapeutic agent.

10. A pharmaceutical composition according to claim 8 in which dl-trans-1-hydroxy-3-(1',2'-dimethylheptyl)-6,6a.beta.,7,8,10,10a.alpha.-h exahydro-6,6-dimethyl-9H-dibenzo[b,d]pyran9-one is the therapeutic agent.

11. A pharmaceutical composition according to claim 8 in which dl-trans-1-hydroxy-3-(1'-methylheptyl)-6,6a,.beta.,7,8,10,10a.alpha. -hexahydro-6,6-dimethyl-9H-dibenzo[b,d]pyran-9-one is the therapeutic agent.

Make Better Decisions: Try a trial or see plans & pricing

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.