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Claims for Patent: 3,928,598

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Claims for Patent: 3,928,598

Title: Hexahydro-dibenzo[b,d]pyran-9-ones as an anti-anxiety drug
Abstract:Use of 1-hydroxy-3-alkyl-6,6a,7,8,10,10a-hexahydro-9H-dibenzo[b,d]pyran-9-ones as psychotropic drugs, particularly as anti-anxiety and/or anti-depressant drugs, as sedative and/or analgesic drugs, and pharmaceutical compositions containing same.
Inventor(s): Archer; Robert A. (Indianapolis, IN)
Assignee: Eli Lilly and Company (Indianapolis, IN)
Application Number:05/413,009
Patent Claims: 1. A process for treating mammals suffering for anxiety which comprises administering to a mammal in need of such treatment a dose of a compound represented by the formula ##SPC6##

wherein R' is either C.sub.7 -C.sub.10 normal alkyl or is the group ##EQU3## wherein R" is C.sub.2 -C.sub.7 alkyl and R.sup.v is H or methyl, wherein both R groups are identical and are H or methyl and wherein R'" is H or C.sub.1 -C.sub.4 alkanoyl, in an amount effective to treat anxiety.

2. A process according to claim 1 in which a dose of from 0.1 to 100 mgs per day of the drug is administered.

3. A process according to claim 1 in which a dose of from 1 to 20 mgs. per day of the drug is administered.

4. A process according to claim 1 in which the drug is administered by the oral route.

5. A process according to claim 1 in which dl-trans-1-hydroxy-3-(1',1'-dimethylheptyl)-6,6a.beta.,7,8,10,10a.alpha.-h exahydro-6,6-dimethyl-9H-dibenzo[b,d]pyran-9-one is administered.

6. A process according to claim 1 in which dl-trans-1-hydroxy-3-(1',2'-dimethylheptyl)-6,6a.beta.,7,8,10,10a.alpha.-h exahydro-6,6-dimethyl-9H-dibenzo[b,d]pyran-9-one is administered.

7. A process according to claim 1 in which dl-trans-1-hydroxy-3-(1'-methylheptyl)-6,6a.beta.,7,8,10,10a.alpha.-hexahy dro-6,6-dimethyl-9H-dibenzo[b,d]pyran-9-one is administered.

8. A pharmaceutical composition, in unit dosage form, for the treatment of anxiety, consisting of a pharmaceutical carrier and, as a therapeutic agent, from 0.1 to 25 mg. of a compound of the formula ##SPC7##

wherein R' is either C.sub.7 -C.sub.10 normal alkyl or is ##EQU4## wherein R" is C.sub.2 -C.sub.7 alkyl and R.sup.v is H or methyl, wherein both R groups are identical and are H or methyl and wherein R'" is H or C.sub.1 -C.sub.4 alkanoyl, effective to treat anxiety.

9. A pharamceutical composition according to claim 8 in which dl-trans-1-hydroxy-3-(1',1'-dimethylheptyl)-6,6a.beta.,7,8,10,10a.alpha.-h exahydro-,6,6-dimethyl-9H-dibenzo[b,d]pyran9-one is the therapeutic agent.

10. A pharmaceutical composition according to claim 8 in which dl-trans-1-hydroxy-3-(1',2'-dimethylheptyl)-6,6a.beta.,7,8,10,10a.alpha.-h exahydro-6,6-dimethyl-9H-dibenzo[b,d]pyran9-one is the therapeutic agent.

11. A pharmaceutical composition according to claim 8 in which dl-trans-1-hydroxy-3-(1'-methylheptyl)-6,6a,.beta.,7,8,10,10a.alpha. -hexahydro-6,6-dimethyl-9H-dibenzo[b,d]pyran-9-one is the therapeutic agent.
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