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|Abstract:||1-Hydroxy-3-alkyl-9-keto or 9-hydroxyhexahydro dibenzo[b,d]pyrans, useful as tranquilizers or hypotensive agents are dispersed with PVP or polyethylene glycol.|
|Inventor(s):||Thakkar; Arvind L. (Indianapolis, IN)|
|Assignee:||Eli Lilly and Company (Indianapolis, IN)|
1. A dispersion of 2-20 parts of polyvinylpyrrolidone having a molecular weight in the range 10,000-360,000 with one part of a compound of the formula ##SPC2##
wherein Z is ##EQU4## or ##EQU5## wherein each R is individually hydrogen or C.sub.1 -C.sub.3 alkanoyl, wherein R.sup.3 is hydrogen or methyl, wherein each R.sup.2 is either hydrogen or methyl, and both R.sup.2 groups are the same, and wherein R.sup.1 is C.sub.1 -C.sub.6 alkyl.
2. A dispersion according to claim 1 containing 1 part of 1-hydroxy-3-(1',1'-dimethylheptyl)-6,6-dimethyl-6,6a,7,8,10,10a-hexahydro- 9H-dibenzo[b,d]pyran-9-one and 9 part of a polyvinylpyrrolidone having a molecular weight in the range 10,000-360,000.
3. A dispersion according to claim 1 wherein the compound is 1-hydroxy-3-(1',1'-dimethylheptyl)-6,6-dimethyl-6,6a,7,8,10,10a-hexahydro- 9H-dibenzo[b,d]pyran-9-one.
4. A dispersion according to claim 3 of polyvinylpyrrolidone of molecular weight 40,000 and 1-hydroxy-3-(1',1'-dimethylheptyl)-6,6-dimethyl-6,6a,7,8,10,10a-hexahydro- 9H-dibenzo[b,d]pyran-9-one.
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