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Claims for Patent: 3,885,046

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Claims for Patent: 3,885,046

Title: Meta chloro or fluoro substituted alpha-T-butylaminopropionphenones in the treatment of depression
Abstract:The compounds m-chloro-.alpha.-t-butylaminopropiophenone and m-fluoro-.alpha.-t-butylaminopropiophenone or salts thereof. The compounds are useful in the treatment of mammals suffering from a depressed state.
Inventor(s): Mehta; Nariman B. (Raleigh, NC)
Assignee: Burroughs Wellcome Co. (Research Triangle Park, NC)
Application Number:05/390,845
Patent Claims: 1. A pharmaceutical composition suitable for use in the treatment of the depressed state comprising an antidepressant-effective amount of a compound of the general formula ##SPC3##

wherein X is chlorine or a pharmaceutically acceptable acid addition salt thereof and a pharmaceutically acceptable carrier therefor.

2. A composition as claimed in claim 1 wherein the compound or its acid addition salt thereof is present as 5 to 95% by weight of the composition.

3. A composition as claimed in claim 1 suitable for oral or rectal administration and in the form of a discrete dosage unit containing from 15 to 500 milligram of the compound or a pharmaceutically acceptable acid addition salt thereof calculated as the weight of base present in the composition.

4. A composition as claimed in claim 1 suitable for parenteral administration in the form of a discrete dosage unit containing from 7.5 to 250 milligram of the compound or a pharmaceutically acceptable acid addition salt thereof, calculated as the weight of base in the composition.

5. A tablet suitable for oral administration comprising an antidepressant-effective amount of m-chloro-.alpha.-t-butylaminopropiophenone or m-fluoro-.alpha.-t-butylaminopropiophenone or a pharmaceutically acceptable acid addition salt thereof and a pharmaceutically acceptable carrier.

6. A capsule suitable for oral administration containing an antidepressant-effective amount of m-chloro-.alpha.-t-butylaminopropiophenone or m-fluoro-.alpha.-t-butylaminopropiophenone or a pharmaceutically acceptable acid addition salt thereof and a pharmaceutically acceptable carrier.

7. A sterile solution or suspension suitable for parenteral administration comprising an antidepressant-effective amount of m-chloro-.alpha.-t-butylaminopropiophenone or m-fluoro-.alpha.-t-butylaminopropiophenone or a pharmaceutically acceptable acid addition salt thereof and a pharmaceutically acceptable carrier.

8. A tablet suitable for oral administration comprising 15 to 500 milligram of m-chloro-.alpha.-t-butylaminopropiophenone hydrochloride and a pharmaceutically acceptable carrier.

9. A method of treating a depressed state in mammals which comprises the administration of an effective antidepressive dose to a mammal of a compound of the formula ##SPC4##

wherein X is chlorine or a pharmaceutically acceptable acid addition salt thereof and a pharmaceutically acceptable carrier.

10. A method as claimed in claim 9 comprising the oral or rectal administration of a dose of 10 to 100 milligram per killogram body weight or the mammal, said dose calculated as the base.

11. A method as claimed in claim 9 comprising the parenteral administration of a dose of 5 to 50 milligram per killogram body weight of the mammal, said dose calculated as the base.

12. A method as claimed in claim 9 comprising the administration to a human of an effective-antidepressant dose of m-chloro-.alpha.-t-butylaminopropiophenone hydrochloride.

13. A method according to claim 10 wherein the mammel is a human.

14. A method according to claim 11 wherein the mammal is a human.
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