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Serving leading biopharmaceutical companies globally:

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Chinese Patent Office
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Generated: December 18, 2017

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Claims for Patent: 3,883,545

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Claims for Patent: 3,883,545

Abstract:New 1-hydroxy-2-pyridones of the general formula ##SPC1## In which R.sub.1 is alkyl of 1 to 17 carbon atoms, cycloalkyl of 5 to 8 carbon atoms, cyclohexylalkyl or phenalkyl both having 1 to 3 carbon atoms in the alkylene chain or .alpha.-furyl, all of which may be substituted by halogen and R.sub.2 to R.sub.4 are hydrogen or lower alkyl or 2 adjacent substituents together form a trimethylene or tetramethylene chain, and in which R.sub.1 to R.sub.4 together contain at least 2 carbon atoms, are prepared by contacting unsaturated .delta.-keto esters or mixtures thereof with hydroxylamine and subjecting the products to cyclization. The compounds exhibit antimycotic properties.
Inventor(s): Lohaus; Gerhard (Kelkheim/Taunus, DT), Dittmar; Walter (Hofheim/Taunus, DT)
Assignee: Hoechst Aktiengesellschaft (Frankfurt am Main, DT)
Application Number:05/317,387
Patent Claims: 1. A 1-hydroxy-2-pyridone of the formula ##SPC5##

wherein R.sub.1 is alkyl of 7 to 11 carbon atoms, cycloalkyl of 5 to 8 carbon atoms, cyclohexylalkyl or phenylalkyl both having 1 to 3 carbon atoms in the alkylene chain and wherein phenylalkyl may be substituted in the phenyl ring by one chlorine or fluorine atom, or .alpha.-furyl, and R.sub.3 and R.sub.4 are hydrogen or lower alkyl.

2. A compound of the formula II ##SPC6##

in which R.sub.1 is alkyl containing 7 to 11 carbon atoms and R.sub.3 is lower alkyl.

3. 1-Hydroxy-4-methyl-6-heptyl-2-pyridone.

4. 1-Hydroxy-4-methyl-6-undecyl-2-pyridone.

5. 1-hydroxy-4-methyl-6-cyclohexyl-2-pyridone.

6. 1-hydroxy-4-methyl-6-cyclohexylmethyl-2-pyridone.

7. 1-hydroxy-4-methyl-6-(.beta.-cyclohexylethyl)-2-pyridone.

8. 1-hydroxy-4-methyl-6-(4-chlorobenzyl)-2-pyridone.

9. 1-hydroxy-4-methyl-6-(.alpha.-furyl)-2-pyridone.
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Serving leading biopharmaceutical companies globally:

Cantor Fitzgerald
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Argus Health

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