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Serving hundreds of leading biopharmaceutical companies globally:

US Department of Justice
Boehringer Ingelheim
Express Scripts
Chinese Patent Office

Generated: May 24, 2018

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Claims for Patent: 3,864,487

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Summary for Patent: 3,864,487
Title: Antiarhythmic pharmaceutical preparation containing ethyl 10-.alpha.-morpholylpropionyl) phenthiazine-2-carbamate hydrochloride
Abstract:A method for preparing a novel composition of matter, ethyl 10-(.beta.-morpholylpropionyl)-phenthiazine-2-carbamate hydrochloride, having the formula ##SPC1## Which comprises reacting ethyl phenthiazine-2-carbamate with .beta.-chloropropionyl chloride in an inert organic solvent at the boiling point of the solvent used, condensing the resulting ethyl 10-(.beta.-chloropropionyl)-phenthiazine-2-carbamate with morpholine in an inert organic solvent, treating the ethyl 10-(.beta.-morpholylpropionyl)-phenthiazine-2-carbamate with hydrogen chloride, and separating the desired compound. The novel compound, ethyl 10-(.beta.-morpholylpropionyl)-phenthiazine-2-carbamate hydrochloride, is the active principle of an antiarhythmic pharmaceutical preparation.
Inventor(s): Gritsenko; Anna Nikitichna (Moscow, SU), Vikhlyaev; Jury Ivanovich (Moscow, SU), Zhuravlev; Semen Vladimirovich (Moscow, SU), Kaverina; Natalya Veniaminovna (Moscow, SU), Senova; Zlata Petrovna (Moscow, SU), Ulyanova; Olga Vasilievna (Moscow, SU)
Application Number:05/172,216
Patent Claims: 1. An antiarhythmic pharmaceutical preparation comprising an antiarhythmically effective amount of ethyl 10-(.beta.-morpholylpropionyl)-phenthiazine-2-carbamate hydrochloride and a pharmaceutically acceptable carrier.

2. A pharmaceutical preparation according to claim 1 in the form of a tablet.

3. A pharmaceutical preparation according to claim 1 in the form of a solution.

4. A pharmaceutical preparation according to claim 2 wherein the tablet contains 25 mg of ethyl 10-(.beta.-morpholylpropionyl)-phenthiazine-2-carbamate hydrochloride.

5. A pharmaceutical preparation according to claim 3 wherein the solution contains 2.5 weight percent of ethyl 10-(.beta.-morpholylpropionyl)-phenthiazine-2-carbamate hydrochloride.

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Cantor Fitzgerald
Farmers Insurance

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