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Claims for Patent: 3,862,332

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Claims for Patent: 3,862,332

Title: METHOD OF LOWERING SERUM CHOLESTEROL
Abstract:Methods useful for lowering serum cholesterol in animals comprising administration to the animal of a hypocholesteremic amount of a bis(dialkylphenol) ketone mercaptole compound or a bis(dialkylphenol) mercaptal compound, preferably bis(3,5-di-tert-butyl-4-hydroxyphenyl) acetone mercaptole, and compositions to be employed in practicing the method.
Inventor(s): Barnhart; James W. (Indianapolis, IN), Shea; Philip J. (Zionsville, IN)
Assignee: The Dow Chemical Company (Midland, MI)
Application Number:04/878,256
Patent Claims: 1. A method for lowering serum cholesterol levels in animals comprising administering to an animal a hypocholesteremic amount of a compound corresponding to the formula ##SPC2##

wherein R in each occurrence thereof independently represents loweralkyl of from one to four carbon atoms, inclusive, R.sub.1 represents methyl, and R.sub.2 represents methyl or ethyl.

2. The method of claim 2 wherein R represents tertiary butyl.

3. The method of claim 1 wherein the compound is administered orally.

4. The method of claim 1 wherein the compound is bis(3,5-di-tert-butyl-4-hydroxyphenyl) acetone mercaptole.

5. The method of claim 1 wherein the compound is bis(3,5-di-tert-butyl-4-hydroxyphenyl) butanone mercaptole.

6. The method of claim 1 wherein the compound is bis(3-tert-butyl-4-hydroxy-5-isopropylphenyl) acetone mercaptole.

7. The method of claim 1 wherein the compound is bis(3-tert-butyl-4-hydroxy-5-methylphenyl) acetone mercaptole.

8. A composition for lowering serum cholesterol levels in animals comprising a pharmaceutical carrier having incorporated therein from about 0.02 to about 90 percent by weight of a compound corresponding to the formula ##SPC3##

wherein R in each occurrence thereof independently represents loweralkyl of from one to four carbon atoms, inclusive, R.sub.1 represents methyl, and R.sub.2 represents methyl or ethyl.

9. The composition of claim 8 further comprising a surface active dispersing agent.

10. The composition of claim 8 wherein the compound is bis(3,5-di-tert-butyl-4-hydroxyphenyl) acetone mercaptole.

11. A composition for lowering serum cholesterol levels in animals, said composition being in dosage unit form adapted for administration to animals, each dosage unit containing from about 100 milligrams to about 5 grams per unit of a substituted ketone mercaptole compound corresponding to the formula ##SPC4##

wherein R in each occurrence thereof independently represents loweralkyl of from one to four carbon atoms, inclusive, R.sub.1 represents methyl, and R.sub.2 represents methyl or ethyl, incorporated in a pharmaceutical carrier.

12. The composition of claim 11 wherein the dosage unit is in a form adapted for oral administration to animals.

13. The composition of claim 12 wherein R.sub.2 represents methyl.

14. The composition of claim 13 wherein the compound is bis(3,5-di-tert-butyl-4-hydroxyphenyl) acetone mercaptole.

15. The composition of claim 14 wherein the dosage unit is in a form adapted for oral administration to animals.

16. The composition of claim 15 wherein the pharmaceutical carrier comprises a surface-active dispersing agent.
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