You’re using a public version of DrugPatentWatch with 5 free searches available | Register to unlock more free searches. CREATE FREE ACCOUNT

Last Updated: March 28, 2024

Claims for Patent: 3,862,321


✉ Email this page to a colleague

« Back to Dashboard


Summary for Patent: 3,862,321
Title: ACYL XYLIDIDE LOCAL ANAESTHETICS
Abstract:The 2-alkyl-2-alkylamino-2',6'-acetoxylidide compounds are useful as long lasting local anaesthetics.
Inventor(s): Adams; Herbert John Frederich (Worcester, MA), Kronberg; George Herbert (Worcester, MA), Takman; Bertil Herbert (Worcester, MA)
Assignee: Astra Pharmaceutical Products, Inc. (Worcester, MA)
Application Number:05/447,680
Patent Claims: 1. A local anesthetic composition comprising (a) as its active ingredient a compound having the structural formula ##SPC13##

wherein R.sup.1 is ethyl, propyl or butyl; R.sup.2 and R.sup.3 are each separately selected from the group consisting of methyl, ethyl, propyl and butyl; R.sup.2 together with R.sup.3 is tetramethylene; the total sum of carbon atoms in R.sup.1, R.sup.2 and R.sup.3 is at least six; or a pharmaceutically acceptable salt thereof in an effective amount sufficient to provide local anesthetic effect, together with (b) a nontoxic pharmaceutically acceptable carrier.

2. The composition as defined by claim 1 wherein the active ingredient is 2-diethylamino-2',6'-n-butyroxylidide.

3. The composition as defined by claim 1 wherein the active ingredient is 2-(N-ethyl-n-propylamino)-2',6'-n-butyroxylidide.

4. The composition as defined by claim 1 wherein the active ingredient is 2-diethylamino-2',6'-n-valeroxylidide.

5. The composition as defined by claim 1 wherein the active ingredient is 2-pyrrolidino-2',6'-n-butyroxylidide.

6. The composition as defined by claim 1 wherein the active ingredient is 2-(N-ethyl-n-butylamino)-2',6'-n-butyroxylidide.

7. The composition as defined by claim 1 wherein the active ingredient is 2-dimethylamino-2',6'-caproylxylidide.

8. The composition as defined by claim 1 wherein the active ingredient is 2-pyrrolidino-2',6'-n-valeroxylidide.

9. A method of inducing local anesthesia in animals, which comprises applying to the area of the body to be anesthetized a locally anesthetizing amount of a compound having the structural formula ##SPC14##

wherein R.sup.1 is ethyl, propyl or butyl; R.sup.2 and R.sup.3 are each separately selected from the group consisting of methyl, ethyl, propyl and butyl; R.sup.2 together with R.sup.3 is tetramethylene; the total sum of carbon atoms in R.sup.1, R.sup.2 and R.sup.3 is at least six; or a pharmaceutically acceptable salt thereof.

10. The method as defined by claim 9 wherein said compound is 2-diethylamino-2',6'-n-butyroxylidide.

11. The method as defined by claim 9 wherein said compound is 2-(N-ethyl-n-propylamino)-2',6'-n-butyroxylidide.

12. The method as defined by claim 9 wherein said compound is 2-diethylamino-2',6'-n-valeroxylidide.

13. The method as defined by claim 9 wherein said compound is 2-pyrrolidino-2',6'-n-butyroxylidide.

14. The method as defined by claim 9 wherein said compound is 2-(N-ethyl-n-butylamino)-2',6'-butyroxylidide.

15. The method as defined by claim 9 wherein said compound is 2-dimethylamino-2',6'-caproylxylidide.

16. The method as defined by claim 9 wherein said compound is 2-pyrrolidino-2',6'-n-valeroxylidide.

Make Better Decisions: Try a trial or see plans & pricing

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.