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Generated: June 25, 2017

DrugPatentWatch Database Preview

Claims for Patent: 3,857,952

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Claims for Patent: 3,857,952

Title: CERTAIN BENZENE DERIVATIVES USEFUL IN TREATING CARDIAC DISORDERS
Abstract:Benzene derivatives of the formula: ##SPC1## Wherein R.sup.1 represents alkanoyl amino of not more than nine carbon atoms, R.sup.2 represents alkyl of one through six carbon atoms, and R.sup.3 represents alkyl of one through six carbon atoms or cycloalkyl of three through six carbon atoms, possess pharmacodynamic properties and are useful in the treatment of various cardiac disorders.
Inventor(s): Wooldridge; Kenneth Robert Harry (Brentwood, EN), Basil; Berkeley (Highwood, near Chelmsford, EN)
Assignee: May & Baker Limited (Dagenham, Essex, EN)
Application Number:05/277,607
Patent Claims: 1. A pharmaceutical composition which comprises, as the active ingredient, an effective amount for the treatment or prophylaxis of angina pectoris or cardiac arrhythmia of a compound of the formula: ##SPC7##

wherein R.sup.1 represents alkanoylamino of one through nine carbon atoms, R.sup.2 represents alkyl of one through six carbon atoms, and R.sup.3 represents alkyl of one through six carbon atoms or cycloalkyl of three through six carbon atoms, or a non-toxic acid addition salt thereof, in association with a pharmaceutically-acceptable carrier.

2. A method of treatment or prophylaxis of a cardiac disorder in a patient suffering from angina pectoris or cardiac arrhythmia which comprises administering orally or intravenously to the patient a compound of the formula: ##SPC8##

wherein R.sup.1 represents alkanoylamino of one through nine carbon atoms, R.sup.2 represents alkyl of one through six carbon atoms, and R.sup.3 represents alkyl of one through six carbon atoms or cycloalkyl of three through six carbon atoms, or a non-toxic acid addition salt thereof, when administered orally in an amount between 1 and 10 mg/kg body weight per day and when administered intraveneously in an amount between 0.1 and 0.5 mg/kg body weight per day.

3. The method according to claim 2 in which the said compound is 5'-butyramido-2'-(2-hydroxy-3-isopropylaminopropoxy) acetophenone or a non-toxic acid addition salt thereof.
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Serving 500+ biopharmaceutical companies globally:

Farmers Insurance
Johnson and Johnson
Colorcon
Medtronic
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Merck
Covington
Fish and Richardson
McKinsey
Mallinckrodt

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