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Generated: August 20, 2017

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Title: 15-METHYL AND 15-ETHYL PROSTAGLANDIN ANALOGS
Abstract:Prostaglandin E and F compounds with a methyl or an ethyl substituent at the C-15 position are disclosed. These are useful for the same pharmacological purposes as the unsubstituted prostaglandins.
Inventor(s): Bundy; Gordon L. (Kalamazoo Township, Kalamazoo County, MI)
Assignee: The Upjohn Company (Kalamazoo, MI)
Application Number:05/034,518
Patent Claims: 1. An optically active compound of the formula: ##SPC19##

or a racemic compound of that formula and the mirror image thereof, wherein R.sub.1 is hydrogen, alkyl of one to eight carbon atoms, inclusive, or a pharmacologically acceptable cation, and wherein R.sub.2 is methyl or ethyl.

2. 15-Methyl-PGF.sub. 2.sub..alpha., an optically active compound according to claim 1 wherein R.sub.1 is hydrogen and R.sub.2 is methyl.

3. Racemic 15-methyl-PGF.sub.2.sub..alpha., a compound according to claim 1 wherein R.sub.1 is hydrogen and R.sub.2 is methyl.
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Johnson and Johnson
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Colorcon

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