Generated: April 27, 2017
|Title:||PHENYL BENZOIC ACID COMPOUNDS|
|Abstract:||The invention relates to substituted 5-(phenyl)benzoic acids, esters and non-toxic pharmaceutically accepted salts thereof and processes for their preparation. The substituted 5-(phenyl)benzoic acids are useful as anti-inflammatory compounds.|
|Inventor(s):||Ruyle; William V. (Scotch Plains, NJ), Sarett; Lewis H. (Skillman, NJ), Matzuk; Alexander R. (Colonia, NJ)|
|Assignee:||Merck & Co., Inc. (Rahway, NJ)|
1. A compound of the formula: ##SPC3##
or a pharmaceutically acceptable non-toxic salt thereof wherein X is fluoro;
R.sub.1 is hydroxy, phenoxy, and;
R.sub.2 is hydrogen or lower alkanoyl;
R.sub.3 is hydrogen.
2. A compound of the formula: ##SPC4##
or a pharmaceutically acceptable non-toxic salt thereof wherein R.sub.2 is hydrogen or lower alkanoyl.
3. The compound of claim 2 which is 2-hydroxy-5-(pentafluorophenyl) benzoic acid.
4. The compound of claim 2 which is 2-hydroxy-5-(2'-fluorophenyl)-benzoic acid.
5. The compound of claim 2 which is 2-hydroxy-5-(3'-fluorophenyl)-benzoic acid.
6. The compound of claim 2 which is 2-hydroxy-5-(2',4'-difluorophenyl)-benzoic acid.
7. A compound of the formula:
or a pharmaceutically acceptable non-toxic salt thereof wherein R.sub.2 is hydrogen or acetyl.
8. The compound of claim 7 which is 2-hydroxy-5-(4'-fluorophenyl)benzoic acid.
9. The compound of claim 7 which is 2-acetoxy-5-(4'-fluorophenyl)benzoic acid.
10. The compound of claim 7 wherein R.sub.2 is hydrogen and the pharmaceutically acceptable non-toxic salt is the choline salt of the acid.
11. The compound of claim 1 which is phenyl 2-hydroxy-5-(4'-fluorophenyl)benzoate.
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