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Claims for Patent: 3,686,412

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Claims for Patent: 3,686,412

Title: COMPOSITIONS CONTAINING BIS-CHROMONYL COMPOUNDS FOR INHIBITING ANTIGEN-ANTIBODY REACTIONS
Abstract:Pharmaceutical compositions comprising a pharmaceutical carrier and a bis-chromonyl compound of the formula ##SPC1## And therapeutically acceptable salts, esters and amides thereof, in which R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5 and R.sup.6 are each selected from the group consisting of hydrogen, halogen, hydroxy, lower alkyl, lower alkoxy, hydroxyloweralkyl, haloloweralkyl, hydroxyloweralkoxy, loweralkoxyloweralkoxy and carboxyloweralkoxy; and X is selected from the group consisting of saturated and unsaturated, straight and branched hydrocarbon chains which may be interrupted by a member selected from the group consisting of benzene rings, dioxanyl, oxygen atoms and carbonyl groups, and which may be substituted by a member selected from the group consisting of halogen atoms, hydroxy groups and lower alkoxy groups are active to inhibit antigen-antibody reaction.
Inventor(s): Fitzmaurice; Colin (Holmes Chapel, EN), Lee; Thomas Brian (Holmes Chapel, EN)
Assignee:
Application Number:05/077,711
Patent Claims: 1. A pharmaceutical composition which comprises a pharmaceutical carrier and 1,3-bis(2-carboxy-chromon-5-yloxy)2-hydroxypropane or a therapeutically acceptable ammonium, alkali metal, alkaline earth metal or amine salt thereof, said bis-chromonyl compound being present in an amount of from about 0.5 to about 67 percent by weight of the composition.

2. A composition according to claim 1 wherein the bis-chromonyl compound is in the form of a salt.

3. A composition according to claim 1 in a form suitable for administration by inhalation.

4. A pharmaceutical composition according to claim 1 comprising a solution or suspension of the active ingredient in water.

5. A pharmaceutical composition according to claim 1 in the form of an aerosol formulation.

6. A pharmaceutical composition according to claim 1, comprising the solid active ingredient diluted with a solid diluent.

7. A pharmaceutical composition in dosage unit form which comprises a pharmaceutical carrier and from one to 50 milligrams of 1,3-bis(2-carboxy-chromon-5-yloxy)-2-hydroxypropane or a therapeutically acceptable ammonium, alkali metal, alkaline earth metal or amine salt thereof.

8. A method for inhibiting the effects of the antigen-antibody reaction which comprises administering to the patient, per dose, 1 to 50 milligrams of 1,3-bis(2-carboxy-chromon-5-yloxy)-2-hydroxypropane or a therapeutically acceptable ammonium, alkali metal, alkaline earth metal or amine salt thereof.

9. A method for the prophylactic treatment of asthma which comprises administering to the patient, per dose, 1 to 50 milligrams of 1,3-bis(2-carboxy-chromon-5-yloxy)-2-hydroxypropane or a therapeutically acceptable ammonium, alkali metal, alkaline earth metal or amine salt thereof.

10. A method according to claim 9 wherein the bis-chromonyl compound is employed in the form of a salt.
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