Claims for Patent: 3,681,500

Summary for Patent: 3,681,500

Title:	Spray compositions for treatment of obstructive disorders of the respiratory tract and methods therefor
Abstract:	Inhalation spray compositions for the treatment of obstructive disorders of the respiratory tract, comprising as an active ingredient a physiologically compatible quaternary salt of Nisopropyl-N-methyl-nortropine tropic acid ester, optionally in combination with a mucolytic and/or a bronchospasmolytic.
Inventor(s):	Karl Zeile, Werner Schulz, Rolf Banholzer, Helmut Wick
Assignee:	CH Boehringer Sohn AG and Co KG , Boehringer Ingelheim GmbH
Application Number:	US94951A
Patent Claims:	2. The method according to claim 8, where X is the anion of hydrobromic, nitric or methanesulfonic acid. 3. The method according to claim 8, where X is the anion of hydrobromic acid. 4. The method according to claim 8, which comprises simultaneously administering to said patient per inhalationem and effective bronchospasmolytic amount of a bronchial antispasmodic selected from the group consisting of 1-(3'',5''-dihydroxy-phenyl)-1-hydroxy-2-(1''''-(p-hydroxy-phenyl)-isopropyl -amino)-ethane hydrobromide and N-cyclohexyl-N-methyl-2-(2-amino-3,5-dibromo)-benzylammonium chloride. 5. The method according to claim 8, which comprises simultaneously administering to said patient per inhalationem an effective mucolytic amount of a compound selected from the group consisting of N-acetyl-L(+)-cysteine and cysteine-N-acetic acid hydrochloride. 6. A pharmaceutical inhalation spray composition for treating asthmatic disorders of the respiratory tract, consisting of 0.007 to 1.0 percent weight, based on the total weight of said composition, of a pharmaceutically acceptable quaternary atropinium salt of the formula 7. A composition according to claim 6, wherein said atropinium salt is N-isopropyl-noratropinium methobromide. 8. A pharmaceutical inhalation spray composition for treating asthmatic disorders of the respiratory tract, consisting of 0.007 to 1.0 percent weight, based on the total weight of said composition, of a pharmaceutically acceptable quaternary atropinium salt of the formula 9. A composition according to claim 8, wherein said atropinium salt is N-isopropyl-noratorpinium methobromide. 10. A pharmaceutical inhalation spray composition for treating asthmatic disorders of the respiratory tract, consisting essentially of an effective amount of a pharmaceutically acceptable quaternary atropinium salt of the formula 11. A composition according to claim 10, wherein said non-aqueous liquid carrier is a liquified mixture of monofluoro-trichloro-methane and difluoro-dichloromethane. 12. A composition according to claim 10, wherein said atropinium salt is N-isopropyl-noratropinium methobromide. 13. A composition according to claim 10, which additionally comprises up to 2 percent by weight of sorbitan tri-oleate. -dihydroxy-phenyl)- 14. A composition according to claim 13, which additionally comprises an effective bronchospasmolytic amount of 1-(3'',5''-dhydroxy-phenyl)-1-hydroxy-2-(1''''-(p-hydroxy-phenyl)-isopropyl -amino)-ethan hydrobromide.