Claims for Patent: 12,617,775

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Summary for Patent: 12,617,775

Title:	Processes of making CSF-1R inhibitors and methods of use thereof
Abstract:	The present disclosure relates to processes of making a compound represented by Formula (I) and methods of use thereof.
Inventor(s):	Elena Kostik, Ann Gelormini, Michael D. Kaufman
Assignee:	Deciphera Pharmaceuticals LLC
Application Number:	US19/299,605
Patent Claims:	1. A dihydrate form of the compound of Formula (II): prepared by a process comprising: reacting a compound of Formula (IX): with a compound of Formula (XII): in the presence of a first catalyst to produce a compound of Formula (IV): reacting the compound of Formula (IV) with a compound represented by: in the presence of a second catalyst, to produce a compound of Formula (III): and reacting the compound of Formula (III) with isopropylamine, thereby preparing the compound of Formula (II). 2. A pharmaceutical composition, comprising the dihydrate form of claim 1 and a pharmaceutically acceptable excipient. 3. The dihydrate form of claim 1, wherein the first catalyst is a palladium catalyst. 4. The dihydrate form of claim 1, wherein the first catalyst is selected from the group consisting of Pd(PPh3)4, Pd(OAc)2/SPhos, Pd(dppf)Cl2, Pd(dppf)Cl2·DCM, XPhos Pd G2, and Pd2(dba)3. 5. The dihydrate form of claim 1, wherein the first catalyst is Pd(PPh3)4. 6. The dihydrate form of claim 1, wherein the second catalyst is a palladium catalyst. 7. The dihydrate form of claim 1, wherein the second catalyst is selected from the group consisting of Pd(PPh3)4, Pd(OAc)2/SPhos, Pd(dppf)Cl2, Pd(dppf)Cl2·DCM, XPhos Pd G2, and Pd2(dba)3. 8. The dihydrate form of claim 1, wherein the second catalyst is Pd(PPh3)4.