Last Updated: May 25, 2026

Claims for Patent: 12,551,461

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Summary for Patent: 12,551,461

Title:	Compositions of triglycerides and uses thereof
Abstract:	The present invention includes solid compositions of triglycerides with one or more fatty acids, such as triheptanoin and glycerol phenylbutyrate, and therapeutic use thereof. The solid compositions can be prepared by spray-drying or other processes.
Inventor(s):	John KLOPP, Gabrielle Morris, Emil Kakkis, Steven Jungles
Assignee:	Ultragenyx Pharmaceutical Inc
Application Number:	US18/167,551
Patent Claims:	1. A pharmaceutical composition comprising an active ingredient, diheptanoate, and hexano-diheptanoate, wherein the active ingredient is in the form of triheptanoin oil; wherein the triheptanoin oil has a purity greater than 98%; wherein the composition comprises 0.01% to 1.5% diheptanoate by weight; wherein the composition comprises 0.01% to 1.0% hexano-diheptanoate by weight; wherein glycerol is undetectable in the composition; wherein monoheptanoate is undetectable in the composition; wherein the composition comprises no more than 0.2% water by weight; and wherein the composition is a liquid composition for oral administration to a human. 2. The pharmaceutical composition of claim 1, wherein the composition comprises 0.05% to 0.7% diheptanoate by weight. 3. The pharmaceutical composition of claim 1, wherein the triheptanoin oil has a purity greater than 98.5%. 4. The pharmaceutical composition of claim 1, wherein the total amount of diheptanoate and hexano-diheptanoate in the composition is no more than 1.3% by weight. 5. The pharmaceutical composition of claim 1, wherein the composition has an assay value of the triheptanoin oil between 95% to 103% as measured by Ph. Eur. 2.2.28.

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