Claims for Patent: 12,527,771

Summary for Patent: 12,527,771

Title:	Viral inhibitors, the synthesis thereof, and intermediates thereto
Abstract:	The present disclosure discloses compositions comprising maribavir, methods of providing the same, and compositions providing intermediates useful in providing maribavir. Maribavir is a benzimidazole riboside and is useful as an antiviral.
Inventor(s):	Jeffrey Scott DEPUE, Suresh Kumar Tipparaju, Helge Alfred REISCH, Datong Tang, Kishore Ramachandran
Assignee:	Takeda Pharmaceutical Co Ltd
Application Number:	US19/261,756
Patent Claims:	1. A composition of maribavir and one or more compounds selected from the group consisting of Compound 9, Compound 10, Compound 11, and Compound 12, the composition comprising maribavir and one or more compounds selected from the group consisting of Compound 9, Compound 10, Compound 11, and Compound 12; wherein maribavir has the following structure: and wherein Compound 9, Compound 10, Compound 11, and Compound 12 have the following structures: wherein Compound 9 is present in an amount of 0.1% w/w or less relative to maribavir, Compound 10 is present in an amount of 0.1% w/w or less relative to maribavir, Compound 11 is present in an amount of 0.1% w/w or less relative to maribavir, and Compound 12 is present in an amount of 0.1% w/w or less relative to maribavir. 2. The composition of claim 1, wherein the composition comprises Compound 9. 3. The composition of claim 1, wherein the composition comprises Compound 10. 4. The composition of claim 1, wherein the composition comprises Compound 11. 5. The composition of claim 1, wherein the composition comprises Compound 12. 6. The composition of claim 1, wherein the composition comprises Compound 9, Compound 10, Compound 11, and Compound 12. 7. A pharmaceutical composition comprising a composition of claim 1 and one or more pharmaceutically acceptable excipients. 8. The composition of claim 1, further comprising Compound 4, having the following structure: wherein Compound 4 is present in an amount of 0.1% w/w or less relative to maribavir. 9. The composition of claim 8, wherein Compound 4 is present in an amount of from 0.01% to 0.1% w/w relative to maribavir. 10. A pharmaceutical composition comprising a composition of claim 9 and one or more pharmaceutically acceptable excipients. 11. The composition of claim 8, wherein Compound 4 is present in an amount of 0.05% w/w or less relative to maribavir. 12. The composition of claim 11, wherein Compound 4 is present in an amount of from 0.01% to 0.05% w/w relative to maribavir. 13. A pharmaceutical composition comprising a composition of claim 8 and one or more pharmaceutically acceptable excipients. 14. The composition of claim 8, further comprising Compound 3, having the following structure: wherein Compound 3 is present in an amount of 0.1% w/w or less relative to maribavir. 15. The composition of claim 14, wherein Compound 3 is present in an amount of from 0.01% to 0.1% w/w relative to maribavir and Compound 4 is present in an amount of from 0.01% to 0.1% w/w relative to maribavir. 16. A pharmaceutical composition comprising a composition of claim 15 and one or more pharmaceutically acceptable excipients. 17. The composition of claim 14, wherein Compound 3 is present in an amount of 0.05% w/w or less relative to maribavir and Compound 4 is present in an amount of 0.05% w/w or less relative to maribavir. 18. The composition of claim 17, wherein Compound 3 is present in an amount of from 0.01% to 0.05% w/w relative to maribavir and Compound 4 is present in an amount of from 0.01% to 0.05% w/w relative to maribavir. 19. A pharmaceutical composition comprising a composition of claim 14 and one or more pharmaceutically acceptable excipients.