Claims for Patent: 12,514,857

Title:	Vasoconstriction compositions and methods of use
Abstract:	The invention generally relates to compositions for inducing vasoconstriction. The compositions comprise highly selective alpha-2 adrenergic receptor agonists, at low concentrations, such as below 0.05% weight by volume. The compositions preferably comprise brimonidine. The compositions preferably have pH from about 4.0 to about 7.5.
Inventor(s):	Gerald Horn
Assignee:	Eye Therapies LLC
Application Number:	US18/643,253
Patent Claims:	1. A method selected from the group consisting of reversing rebound hyperemia, reducing eye redness, increasing eye whiteness and a combination thereof, comprising topically administering to a subject in need thereof a composition comprising from about 0.01% to about 0.025% w/v brimonidine or a pharmaceutically acceptable salt thereof, wherein w/v denotes weight by total volume of the composition. 2. The method of claim 1, wherein brimonidine or a pharmaceutically acceptable salt thereof is at a concentration of about 0.025% w/v. 3. The method of claim 1, wherein the composition has a pH from about 5.5 to about 6.5. 4. The method of claim 1, wherein the composition is formulated as an ocular drop.