Last Updated: May 11, 2026

Claims for Patent: 12,447,241

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Summary for Patent: 12,447,241

Title:	Multi-unit drug delivery devices and methods
Abstract:	Implantable drug delivery devices include a housing defining a reservoir, a first unit within the reservoir, and a second unit within the reservoir. The first unit contains a drug and the second unit contains a functional agent that facilitates release of the drug. Intravesical drug delivery devices include a housing portion containing a drug formulation and a housing portion containing an excipient, and are configured to release the drug according to a first release profile and the excipient according to a second release profile. Methods include inserting any of these devices into a patient and releasing drug from the device.
Inventor(s):	Heejin Lee, Karen Daniel, Matthew Sansone
Assignee:	Taris Biomedical LLC
Application Number:	US16/936,554
Patent Claims:	1. A drug formulation consisting of: a first plurality of mini-tablets each consisting of: 80.0% by weight gemcitabine HCI; 13.3% by weight urea; 4.2% by weight polyvinylpyrrolidone; and 2.5% by weight polyethylene glycol 8000; and a second plurality of mini-tablets each consisting of: 90% by weight urea; and 10% by weight one or more excipients. 2. The drug formulation of claim 1, wherein each of the first and second pluralities of mini-tablets has a diameter between 1.5 mm and 3.1 mm. 3. The drug formulation of claim 2, wherein each of the first and second pluralities of mini-tablets has a length between 2.0 mm and 4.5 mm. 4. The drug formulation of claim 1, wherein each of the first and second pluralities of mini-tablets has a diameter of about 2.64 mm. 5. The drug formulation of claim 4, wherein each of the first and second pluralities of mini-tablets has a length between 2.0 mm and 4.5 mm. 6. The drug formulation of claim 5, wherein each of the first and second pluralities of mini-tablets has an aspect ratio of height: width of 3:2. 7. The drug formulation of claim 1, wherein each of the first and second pluralities of mini-tablets has an aspect ratio of height: width from 3:2 to 5:2.

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