You're using a free limited version of DrugPatentWatch: Upgrade for Complete Access

Last Updated: December 15, 2025

Claims for Patent: 12,427,207

✉ Email this page to a colleague

« Back to Dashboard

Summary for Patent: 12,427,207

Title:	Pharmaceutical formulations
Abstract:	The present invention relates to a pharmaceutical composition comprising a radiohybrid agent containing a silicon-fluoride and a chelating group wherein either the fluorine is 18F or the chelating group contains a chelated radioactive metal, wherein the composition has a ph of 4.0-6.0 and further comprises: 0.1-200 mM citrate buffer; 1-100 mg/ml ethanol; and 5-10 mg/ml sodium chloride.
Inventor(s):	Romain Bejot, Michael Haka, Atilio Anzellotti
Assignee:	Blue Earth Diagnostics Ltd , Siemens Medical Solutions USA Inc
Application Number:	US18/435,245
Patent Claims:	1. A pharmaceutical composition comprising a radiohybrid agent containing a silicon-fluoride group and a chelating group, wherein either the fluorine of the silicon-fluoride group is 18F or the chelating group contains a chelated radioactive metal, wherein the radiohybrid agent is: or an isomer or salt thereof, wherein M3+is a chelated radioactive or non-radioactive metal, and wherein the composition has a pH of 4.0-6.0 and further comprises 0.1-200 mM citrate buffer. 2. The pharmaceutical composition of claim 1 comprising 1-15 mM citrate buffer. 3. The pharmaceutical composition of claim 2 comprising 1.1 mM (±10%) citrate buffer. 4. The pharmaceutical composition of claim 1 that has a pH of 4.5 to 5.5. 5. The pharmaceutical composition of claim 1 that has a pH of 5.0. 6. The pharmaceutical composition of claim 5 comprising 5-50 mg/mL ethanol. 7. The pharmaceutical composition of claim 1 wherein the fluorine is 18F and M3+is a chelated non-radioactive metal. 8. The pharmaceutical composition of claim 7 wherein the metal is Ga.

Make Better Decisions: Try a trial or see plans & pricing

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. We do not provide individual investment advice. This service is not registered with any financial regulatory agency. The information we publish is educational only and based on our opinions plus our models. By using DrugPatentWatch you acknowledge that we do not provide personalized recommendations or advice. thinkBiotech performs no independent verification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.