Claims for Patent: 12,415,784

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Summary for Patent: 12,415,784

Title:	Cabozantinib compositions and methods of use
Abstract:	The present invention relates to oral compositions comprising cabozantinib salts and at least one pharmaceutically acceptable excipient and methods of using the oral compositions to increase the oral bioavailability of the cabozantinib and reduce the adverse events associate with the oral administration of cabozantinib. The invention also relates to methods for preparing cabozantinib lauryl sulfate salts.
Inventor(s):	Fang-Yu Liu, K.C. Sung, Yu Zhang, Shang Wei Qin, John Duan, George Kraft
Assignee:	Handa Oncology LLC
Application Number:	US18/938,926
Patent Claims:	1. A crystalline cabozantinib lauryl sulfate salt characterized by an x-ray powder diffraction (XRPD) pattern with 2θ peaks at 5.0±0.2, 12.1±0.2, 16.6±0.2, and 16.9±0.2. 2. The crystalline cabozantinib lauryl sulfate salt of claim 1 further comprising one or more XRPD 2θ peaks selected from the group consisting of 19.1±0.2, 24.5±0.2 and 29.5±0.2. 3. The crystalline cabozantinib lauryl sulfate salt of claim 1 comprising XRPD 2θ peaks at 5.0±0.2, 12.1±0.2, 16.6±0.2, 16.9±0.2, 19.1±0.2, 24.5±0.2 and 29.5±0.2. 4. A crystalline cabozantinib lauryl sulfate salt characterized by an x-ray powder diffraction (XRPD) pattern with 2θ peaks at 5.0±0.2, 12.1±0.2, 15.9±0.2, 16.6±0.2, and 16.9±0.2. 5. The crystalline cabozantinib lauryl sulfate salt of claim 4 further comprising one or more XRPD 2θ peaks selected from the group consisting of 19.2±0.2, 24.4±0.2 and 29.5±0.2. 6. The crystalline cabozantinib lauryl sulfate salt of claim 4 comprising XRPD 2θ peaks at 5.0±0.2, 12.1±0.2, 15.9±0.2, 16.6±0.2, 16.9±0.2, 19.2±0.2, 24.4±0.2 and 29.5±0.2.