Claims for Patent: 12,403,109

Summary for Patent: 12,403,109

Title:	Sotalol hydrochloride dosing
Abstract:	The present invention provides novel methods of administering sotalol hydrochloride to patients in need thereof.
Inventor(s):	John Somberg, Brandon Ira Kashfian, Janos Molnar
Assignee:	Altathera Pharmaceuticals LLC
Application Number:	US17/725,189
Patent Claims:	1. A method of administering sotalol hydrochloride, comprising: a. administering an intravenous (IV) dose of 125-135 mg sotalol hydrochloride over a period of 1 hour to a subject having had symptomatic atrial fibrillation or atrial flutter, wherein the subject is currently in sinus rhythm; and b. after completion of the IV dose, administering oral dosing of one or more oral dose of sotalol hydrochloride to the subject in an amount of 120 mg. 2. The method of claim 1, wherein the oral dosing is initiated 4-12 hours after completion of the IV dose. 3. The method of claim 1, wherein one or more of the oral doses are administered at a 12-48 hour interval from initiation of the oral dosing. 4. The method of claim 3, wherein: the oral dosing is initiated 4-6 hours after completion of the IV dose; and one or more of the oral doses are administered at a 12-24 hour interval from initiation of the oral dosing. 5. The method of claim 3, wherein the oral dosing is initiated 4-12 hours after completion of the IV dose. 6. The method of claim 2, wherein: the oral dosing is initiated 4-6 hours after completion of the IV dose; and one or more of the oral doses are administered at a 12-48 hour interval from initiation of the oral dosing. 7. The method of claim 6, wherein: one or more of the oral doses are administered at a 12 hour interval from initiation of the oral dosing.