Claims for Patent: 12,350,382

Summary for Patent: 12,350,382

Title:	Method for preparing particles comprising metal oxide coating and particles with metal oxide coating
Abstract:	The invention relates to a process for coating a solid, water-insoluble particulate matter, with a metal oxide comprising: (a) contacting the solid, water-insoluble particulate matter with an ionic additive and an aqueous medium to obtain a dispersion of said particulate matter having positive charges on its surface; (b) subjecting the particulate matter to a coating procedure comprising precipitating a metal oxide salt onto the surface of the particulate matter to form a metal oxide layer thereon to thereby obtain particulate matter coated by a metal oxide coating layer; (c) repeating step (b) at least 4 more times; and (d) aging said coating layer. The invention further relates to particles comprising a particulate matter coated by a metal oxide layer, to a use of the particles for topical administration, and to a method for preventing, reducing, or eliminating pests at a locus, using the particles.
Inventor(s):	Ofer Toledano, Haim Bar-Simantov, Nissim Bilman, Leora Shapiro, Raed Abu-Reziq, Srikanth Sriadibhatla, William T. Sommer, Hanan Sertchook
Assignee:	Mayne Pharma LLC
Application Number:	US12/525,331
Patent Claims:	1. A process for coating solid benzoyl peroxide consisting of: (a) contacting, in an aqueous medium, the solid benzoyl peroxide with a cationic surfactant to obtain a dispersion of solid benzoyl peroxide having positive charges on its surface; (b) adding an aqueous solution of a metal oxide salt to said dispersion, under conditions wherein said metal oxide salt precipitates onto the benzoyl peroxide, and acidifying to thereby form benzoyl peroxide that has a metal oxide layer coated thereon; (b1) contacting, in an aqueous medium, the benzoyl peroxide coated with a metal oxide layer of the preceding step with a surface adhering additive being one or both of (i) a cationic polymer additive and (ii) a non-ionic additive, to obtain a dispersion of said coated solid benzoyl peroxide having an adhering additive on the surface thereof; (b2) bringing the dispersion obtained in step (b1) into contact with an aqueous solution of a metal oxide salt, under conditions wherein said metal oxide salt precipitates onto the surface of said coated solid benzoyl peroxide, and acidifying to thereby form a solid benzoyl peroxide that has a further metal oxide layer coated thereon; (c) repeating steps (b1) and (b2) at least 3 more times; (d) after completion of step (c), aging the metal oxide coating at a temperature ranging between 4° C. and 90° C. and at a pH of 3-9 to form a coated solid benzoyl peroxide, wherein no aging step is conducted between repeated coating steps, but only after completion of step c; and, optionally, (e) separating the coated, solid benzoyl peroxide from the aqueous medium and optionally rinsing and re-dispersing the coated, solid benzoyl peroxide in an aqueous medium. 2. The process of claim 1, wherein, in step (a), the solid, benzoyl peroxide is further contacted with an anionic additive. 3. The process of claim 1, wherein said cationic surfactant additive in step (a) is selected from the group consisting of monoalkylquaternary ammonium salts, dialkyl quaternary ammonium salts, and mixtures thereof. 4. Coated solid benzoyl peroxide obtained by the process according to claim 1. 5. The coated solid benzoyl peroxide of claim 4, wherein the weight ratio of the metal oxide to said solid benzoyl peroxide is in the range of 1:99 to 40:60. 6. A method for treating a surface condition in a subject, comprising topically administering onto the surface a composition comprising a coated solid benzoyl peroxide according to claim 4, wherein said surface condition is a disease or disorder selected from the group consisting of acne, infection, inflammation, pruritus, psoriasis, seborrhea, contact dermatitis, rosacea, and a combination thereof. 7. The method of claim 6, wherein said surface is skin or mucosal membrane. 8. The process of claim 1, wherein said metal oxide salt is an alkali metal salt of a metal oxide. 9. The process of claim 1, wherein the thickness of the metal oxide coating of benzoyl peroxide following step (d) is between 0.1-10 micron. 10. The process of claim 1, wherein said metal oxide is selected from silica, titania, alumina, zirconia, ZnO, and mixtures thereof. 11. The process of claim 10, wherein the metal oxide is silica.