Claims for Patent: 12,350,262

Summary for Patent: 12,350,262

Title:	Methods of treatment for cystic fibrosis
Abstract:	Compound I of the formulaand/or pharmaceutically acceptable salt(s) of Compound I comprised in a pharmaceutical composition and methods of using the same to treat cystic fibrosis.
Inventor(s):	Weichao George Chen, Eric L Haseltine, Samuel Moskowitz, Sarah Robertson, David Waltz
Assignee:	Vertex Pharmaceuticals Inc
Application Number:	US17/899,660
Patent Claims:	1. A method of treating cystic fibrosis comprising administering to a patient in need thereof: (a) 200 mg once daily of crystalline Form A of Compound I: (b) 100 mg once daily of amorphous Compound II: and (c) 150 mg per dose twice daily of amorphous Compound III: 2. A method of treating cystic fibrosis comprising administering to a patient in need thereof: (a) 100 mg once daily of crystalline Form A of Compound I: (b) 50 mg once daily of amorphous Compound II: and (c) 75 mg per dose twice daily of amorphous Compound III: 3. The method of claim 1, wherein the method comprises administering 200 mg of Compound I, 100 mg of Compound II, and 150 mg of Compound III; followed by administering 150 mg of Compound III 12 hours later. 4. The method of claim 2, wherein the method comprises administering 100 mg of Compound I, 50 mg of Compound II, and 75 mg of Compound III; followed by administering 75 mg of Compound III 12 hours later.