Claims for Patent: 12,350,259

Summary for Patent: 12,350,259

Title:	Methods of treating migraine
Abstract:	The present disclosure provides methods for the treatment of migraine by the administration of atogepant or a pharmaceutically acceptable salt thereof.
Inventor(s):	Ramesh BOINPALLY, Joel Trugman
Assignee:	Allergan Pharmaceuticals International Ltd
Application Number:	US17/953,536
Patent Claims:	1. A method for the preventive treatment of migraine in a patient undergoing concurrent treatment with a strong CYP3A4 inhibitor, the method comprising orally administering 10 mg atogepant once daily to the patient, wherein the patient's migraines are safely and effectively treated. 2. The method according to claim 1, wherein coadministration of atogepant and the strong CYP3A4 inhibitor results in an increase in atogepant Cmax of less than 2.15-fold relative to administration of atogepant alone. 3. The method according to claim 1, wherein coadministration of atogepant and the strong CYP3A4 inhibitor results in an increase in atogepant AUC of about 5.5-fold relative to administration of atogepant alone. 4. The method according to claim 1, wherein the CYP3A4 inhibitor is selected from the group consisting of ketoconazole, itraconazole, or clarithromycin. 5. The method according to claim 1, wherein the CYP3A4 inhibitor is itraconazole. 6. The method of claim 1, wherein the migraine is episodic migraine. 7. The method of claim 4, wherein the migraine is episodic migraine.