Last Updated: May 10, 2026

Claims for Patent: 12,296,011

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Summary for Patent: 12,296,011

Title:	Methods for photodynamic therapy
Abstract:	A method of enhancing penetration of a topical composition of 5-aminolevulinic acid (ALA) into tissue for photodynamic therapy includes topically applying ALA to a treatment area to be treated with photodynamic therapy. The method further includes, after the ALA is applied to the treatment area, covering the treatment area with a low density polyethylene barrier. The treatment area is covered with the low density polyethylene barrier prior to light treatment to minimize transepidermal water loss from the treatment area.
Inventor(s):	Scott Lundahl, Michael Guttadauro
Assignee:	Sun Pharmaceutical Industries Inc
Application Number:	US18/313,162
Patent Litigation and PTAB cases:	See patent lawsuits and PTAB cases for patent 12,296,011
Patent Claims:	1. A method of treating a lesion, the method comprising: providing, via an applicator, a topical composition comprising 5-aminolevulinic acid (ALA); applying the topical composition comprising the ALA onto a portion of skin containing the lesion, the portion of skin being on an extensor surface of a patient's body, wherein applying the topical composition via the applicator comprises controlling a dispersion of the topical composition; providing, via the dispersion of the topical composition, uniform wetting of the portion of skin containing the lesion; incubating the portion of the skin containing the lesion; applying a barrier directly on the wetted portion of the skin; and irradiating, via a light source, the portion of skin for a first time period. 2. The method of claim 1, further comprising determining an accumulation of protoporphyrin IX (PpIX) in the treatment area. 3. The method of claim 1, wherein the barrier comprises a polyethylene barrier or a foil barrier. 4. The method of claim 1, wherein a concentration of the ALA within the topical composition is 20% w/w or 10% w/w. 5. The method of claim 1, wherein irradiating the portion of skin comprises irradiating the portion of skin with a first light wavelength and subsequently irradiating the portion of skin with a second light wavelength. 6. The method of claim 5, wherein the first light wavelength corresponds to blue light and the second light wavelength corresponds to red light.

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