Claims for Patent: 12,290,651

Summary for Patent: 12,290,651

Title:	Devices and methods for the treatment of body surface disorders
Abstract:	Applicator devices (1), kits, systems, and methods of using such devices for treating one or more body surface conditions (e.g., warts, Molluscum contagiosum, conjunctivitis, otitis) are provided. The applicator device facilitates topical administration of a controllable amount of a pharmaceutical composition to a desired area of an affected body surface (e.g., skin, eye, ear, nose, mouth, anus, vagina). The applicator device includes an ampule (40) containing the pharmaceutical composition, the ampule being positioned within a tube (50). Squeezing the tube breaks the ampule, releasing the pharmaceutical composition. The applicator device includes a filter (30) that permits passage of fluid and inhibits passage of broken ampule shards. The applicator device includes a dispensing tip (20) through which the pharmaceutical composition passes.
Inventor(s):	Matthew Gene Davidson, Jayson Michael Rieger, Eugene Scavola, Paul Daly, Howard Welgus
Assignee:	Verrica Pharmaceuticals Inc
Application Number:	US16/621,854
Patent Claims:	1. An applicator device for dispensing a pharmaceutical composition for topical administration of the pharmaceutical composition to a subject, comprising: a tube; an ampule positioned within the tube; a pharmaceutical composition contained within the ampule; a dispenser tip attached to the tube, the dispenser tip having a tapered tip and a drip guard comprising a trough configured to receive fluid running down an outer surface of the tapered tip, wherein the drip guard includes one or more grooves formed on an external side of the drip guard. 2. The applicator device of claim 1, further comprising a filter positioned within the tapered tip of the dispenser tip, the filter being constructed and arranged to permit passage of fluid and inhibit passage of broken ampule shards having a particle size of at least 150 um. 3. The applicator device of claim 2, wherein the filter is held within the dispenser tip via an interference fit between the filter and an inner surface of the tapered tip. 4. The applicator device of claim 1, wherein the tapered tip of the dispenser tip is configured to dispense discrete droplets of the pharmaceutical composition. 5. The applicator device of claim 1, wherein the dispenser tip includes an inner surface and an outer surface, wherein at least a portion of the inner surface is tapered at a first taper angle and at least a portion of the outer surface is tapered at a second taper angle. 6. The applicator device of claim 5, wherein the second taper angle is different from the first taper angle. 7. The applicator device of claim 1, wherein the dispenser tip includes a first portion and a second portion, wherein the first portion has a tapering inner diameter, and the second portion has a constant inner diameter. 8. The applicator device of claim 1, wherein the tapered tip ends in a distal opening having an internal diameter of less than 0.02 inches and external diameter of less than 0.05 inches. 9. The applicator device of claim 1, further comprising a cap having an opening for receiving the dispenser tip, wherein the cap has a closed position in which at least a portion of the dispenser tip is passed through the opening, and wherein the cap is coupled to the dispenser tip and positioned over at least a portion of the dispenser tip. 10. The applicator device of claim 9, wherein when the cap is in the closed position, venting of the dispenser tip is permitted through the opening of the cap. 11. The applicator device of claim 10, wherein venting of the dispenser tip occurs only through the opening of the cap. 12. The applicator device of claim 10, wherein venting of the dispenser tip is permitted through the opening of the cap at locations adjacent the one or more grooves formed on the external side of the drip guard. 13. The applicator device of claim 1, wherein at least a portion of the dispenser tip is attached to the tube to form a fluid-tight seal between the dispenser tip and the tube. 14. The applicator device of claim 1, wherein the applicator device is constructed and arranged to create a vacuum inside the tube when the tube is squeezed and then released. 15. The applicator device of claim 1, wherein the pharmaceutical composition comprises a compound selected from the group consisting of: cantharidin, antifungals, antibacterials, antivirals, corticosteroids, steroids, immunostimulants, chemotherapeutics, keratolytics, antihistamines, and anti-inflammatory agents. 16. The applicator device of claim 1, wherein the pharmaceutical composition comprises cantharidin, acetone, ethanol, a plasticizer, and a film-forming agent. 17. The applicator device of claim 16, wherein the composition further comprises hydroxypropylcellulose, nitrocellulose, castor oil, camphor, denatonium benzoate, and gentian violet. 18. The applicator device of claim 17, wherein the composition further comprises ether. 19. The applicator device of claim 1, wherein the composition is ether-free. 20. An applicator device for dispensing a pharmaceutical composition for topical administration of the pharmaceutical composition to a subject, comprising: a tube; an ampule positioned within the tube; a pharmaceutical composition contained within the ampule; a dispenser tip attached to the tube, the dispenser tip having a tapered tip and a drip guard comprising a trough configured to receive fluid running down an outer surface of the tapered tip, wherein the drip guard includes one or more grooves formed on an external side of the drip guard, and wherein the pharmaceutical composition comprises: greater than or equal to 25 and less than or equal to 35 weight per weight percent of ethanol; greater than or equal to 55 and less than or equal to 65 weight per weight percent of acetone; less than or equal to 10 weight per weight percent of ether; greater than or equal to 0.1 and less than or equal to 2 weight per weight percent of hydroxypropylcellulose; greater than or equal to 2.0 and less than or equal to 10 weight per weight percent of nitrocellulose; greater than or equal to 0.5 and less than or equal to 2 weight per weight percent of castor oil; greater than or equal to 0.1 and less than or equal to 1.5 weight per weight percent of cantharidin; greater than or equal to 0.001 and less than or equal to 0.01 weight per weight percent of denatonium benzoate; and greater than or equal to 0.0001 and less than or equal to 0.001 weight per weight percent of gentian violet.