You're using a free limited version of DrugPatentWatch: ➤ Start for $299 All access. No Commitment.

Last Updated: December 17, 2025

Claims for Patent: 12,268,666

✉ Email this page to a colleague

« Back to Dashboard

Summary for Patent: 12,268,666

Title:	Spray-dried dispersions, formulations, and polymorphs of (S)-5-amino-3-(4-((5-fluoro-2-methoxybenzamido)methyl)phenyl)-1-(1,1,1-trifluoropropan-2-yl)-1H-pyrazole-4-carboxamide
Abstract:	A spray-dried dispersions and pharmaceutical composition of (S)-5-amino-3-(4-((5-fluoro-2-methoxybenzamido)methyl)phenyl)-1-(1,1,1-trifluoropropan-2-yl)-1H-pyrazole-4-carboxamide, pharmaceutically acceptable salts thereof, or a combination thereof and the use of the spray-dried dispersion and pharmaceutical composition in the treatment of cancer and autoimmune and inflammatory diseases are disclosed. Also provided are crystalline forms of (S)-5-amino-3-(4-((5-fluoro-2-methoxybenzamido)methyl)phenyl)-1-(1,1,1-trifluoropropan-2-yl)-1H-pyrazole-4-carboxamide also useful in the treatment of cancer and autoimmune and inflammatory diseases.
Inventor(s):	Barbara J. Brandhuber, Lauren T. Brent, Charles Todd Eary, Andrew Kenna, Firas Khan, Vivian F. H. Renshaw, Stacey Renee Spencer
Assignee:	Loxo Oncology Inc
Application Number:	US18/440,563
Patent Claims:	1. A spray-dried dispersion comprising a compound of Formula I: or a pharmaceutically acceptable salt thereof and one or more polymers selected from the group consisting of an HPMCAS polymer, an HPMC polymer, a vinylpyrrolidone-vinyl acetate copolymer, and a polyvinylpyrrolidone (PVP) polymer. 2. The spray-dried dispersion according to claim 1, comprising the compound of Formula I. 3. The spray-dried dispersion according to claim 2, wherein the compound of Formula I is present in amorphous form. 4. The spray-dried dispersion according to claim 3, comprising the compound of Formula I and an HPMCAS polymer. 5. The spray-dried dispersion according to claim 4, wherein the ratio of the compound of Formula I to the HPMCAS polymer is about 1:4 to about 4:1. 6. The spray-dried dispersion according to claim 4, wherein the ratio of the compound of Formula I to the HPMCAS polymer is about 1:1. 7. The spray-dried dispersion according to claim 6, wherein the HPMCAS polymer is one or more of HPMCAS-MG, HPMCAS-LF, HPMCAS-LG, HPMCAS-MF, HPMCAS-HF, or HPMCAS-HG. 8. The spray-dried dispersion according to claim 7, wherein the HPMCAS polymer is HPMCAS-MG.

Make Better Decisions: Try a trial or see plans & pricing

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. We do not provide individual investment advice. This service is not registered with any financial regulatory agency. The information we publish is educational only and based on our opinions plus our models. By using DrugPatentWatch you acknowledge that we do not provide personalized recommendations or advice. thinkBiotech performs no independent verification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.