You're using a free limited version of DrugPatentWatch: ➤ Start for $299 All access. No Commitment.

Last Updated: December 18, 2025

Claims for Patent: 12,180,219

✉ Email this page to a colleague

« Back to Dashboard

Summary for Patent: 12,180,219

Title:	Process for preparing beta 3 agonists and intermediates
Abstract:	The application is directed to efficient and economical processes as described in more detail below for the preparation of the beta 3 agonists of the formula of I-7 and intermediate compounds that can be used for making these agonists. The present disclosure relates to a process for making beta-3 agonists and intermediates using ketoreductase (KRED) biocatalyst enzymes and methods of using the biocatalysts.
Inventor(s):	Feng Xu, Zhuqing Liu, Richard Desmond, Jeonghan Park, Alexei Kalinin, Birgit Kosjek, Hallena Strotman, Hongmei Li, Johannah Moncecchi
Assignee:	Merck Sharp and Dohme LLC
Application Number:	US18/649,712
Patent Claims:	1. A crystalline form of Compound I-7: characterized by a powder X-ray diffraction (XRPD) pattern comprising °2θ peaks at about 5.5, 8.7, and 11.0. 2. The crystalline form of Compound I-7 of claim 1, wherein the crystalline form is characterized by the XRPD pattern further comprising a °2θ peak at about 17.5. 3. The crystalline form of Compound I-7 of claim 1, wherein the crystalline form is characterized by the XRPD pattern further comprising a °2θ peak at about 22.7. 4. The crystalline form of Compound I-7 of claim 1, wherein the crystalline form is characterized by the XRPD pattern further comprising °2θ peaks at about 17.5 and 22.7. 5. The crystalline form of Compound I-7 of claim 1, characterized by an XRPD pattern as shown in FIG. 2 . 6. The crystalline form of Compound I-7 of claim 1 which is anhydrous. 7. The crystalline form of Compound I-7 of claim 1, wherein the crystalline form is characterized by an XRPD pattern comprising the following reflections with d-spacing: Position [°2 Theta] d-spacing [Å] 5.4897 16.09873 8.7494 10.10683 11.0426 8.01261 16.4521 5.38818 16.6518 5.32402 17.4975 5.06857 18.853 4.7071 21.2176 4.18756 21.7532 4.08564 22.7425 3.9101 8. A composition comprising the crystalline form of Compound I-7 of claim 1.

Make Better Decisions: Try a trial or see plans & pricing

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. We do not provide individual investment advice. This service is not registered with any financial regulatory agency. The information we publish is educational only and based on our opinions plus our models. By using DrugPatentWatch you acknowledge that we do not provide personalized recommendations or advice. thinkBiotech performs no independent verification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.