Claims for Patent: 12,171,772

Summary for Patent: 12,171,772

Title:	Therapeutic uses of pharmaceutical compositions comprising cyclic boronic acid ester derivatives
Abstract:	Disclosed herein are antimicrobial compounds compositions, pharmaceutical compositions, the use and preparation thereof. Some embodiments relate to cyclic boronic acid ester derivatives and their use as therapeutic agents.
Inventor(s):	Gavin Hirst, Raja Reddy, Scott J. Hecker, Maxim Totrov, David C. Griffith, Olga Lomovskaya, Michael N. Dudley, Serge Henri Boyer
Assignee:	Melinta Subsidiary Corp
Application Number:	US18/314,560
Patent Claims:	1. A crystalline form of 2-((3R,6S)-2-hydroxy-3-(2-(thiophen-2-yl)acetamido)-1,2-oxaborinan-6-yl)acetic acid: 2. The crystalline form of claim 1, wherein the crystalline form has an X-ray powder diffraction pattern comprising three or more characteristic peaks expressed in degrees two-theta to within 0.2° selected from 9.0°, 15.7°, 17.3°, 17.6°, 18.1°, 21.3°, 22.4°, 23.5°, 24.9°, 27.2°, 27.4°, 28.1°, 29.1°, 31.2°, and 35.7°. 3. The crystalline form of claim 1, wherein the crystalline form has an X-ray powder diffraction pattern comprising characteristic peaks expressed in degrees two-theta to within 0.2° at 9.0°, 17.3°, and 18.1°. 4. The crystalline form of claim 1, wherein the crystalline form has an X-ray powder diffraction pattern substantially identical to FIG. 3 . 5. The crystalline form of claim 1 or 2, wherein the crystalline form has a melting point of about 155° C.