Claims for Patent: 12,161,653

Summary for Patent: 12,161,653

Title:	Treatment of submental fat
Abstract:	This disclosure relates to compositions, kits and methods for non-surgical reduction of localized subcutaneous fat such as that associated with a cosmetic fat accumulation. The methods employ compositions having specific concentrations of a salt of deoxycholic acid which provides a superior fat cell necrosis with modest adverse effects. Examples of localized subcutaneous fat are found in the submental area, in particular under the chin.
Inventor(s):	Patricia Walker
Assignee:	Allergan Sales LLC
Application Number:	US17/752,056
Patent Claims:	1. A method for decreasing submental fat in a subject, said method comprising (a) applying a grid pattern to mark injection sites spaced about 1.0 cm apart from each other at a treatment area of the subject; and (b) administering a plurality of up to 50 subcutaneous 0.2-mL injections to the treatment area as marked by the grid pattern; wherein each injection comprises a phosphatidylcholine-free solution comprising about 2 mg of deoxycholic acid, or a salt thereof; and steps (a) and (b) are repeated up to 6 times at intervals no less than 1 month apart. 2. The method of claim 1, further comprising massaging the treatment area after completion of the administration of the plurality of subcutaneous injections. 3. The method of claim 1, wherein the plurality of subcutaneous injections has a total volume of up to 10 mL. 4. The method of claim 1, wherein each injection is administered using a syringe with a 30-gauge, 0.5-inch needle. 5. The method of claim 1, further comprising administering to the subject an agent selected from the group consisting of anesthetic agents, anti-microbial agents, vasoconstrictors, anti-thrombotic agents, anti-coagulation agents, suds-depressants, anti-inflammatory agents, analgesics, dispersion agents, anti-dispersion agents, penetration enhancers, steroids, tranquilizers, muscle relaxants, anti-diarrhea agents, and any combinations thereof. 6. The method of claim 1, further comprising administering lidocaine to the treatment area prior to the administering of the plurality of subcutaneous injections. 7. The method of claim 1, wherein each injection further comprises a lipase. 8. The method of claim 1, wherein the solution further comprises benzyl alcohol at a concentration of about 0.8% w/w to about 1% w/w. 9. The method of claim 8, wherein the solution further comprises sodium phosphate.