Claims for Patent: 12,133,919

Summary for Patent: 12,133,919

Title:	Stabilized microcapsules, method of their preparation and uses thereof
Abstract:	The present application is directed to stabilized core-shell microcapsules comprising a core of benzoyl peroxide (BPO) or all trans retinoic acid (ATRA) and a metal-oxide shell; and to pharmaceutical compositions and methods of use thereof.
Inventor(s):	Ofer Toledano, Karine Neimann, Danil FINKEL-MOISEEV, Maya Erlich, Dorit Marco
Assignee:	Mayne Pharma LLC
Application Number:	US17/327,729
Patent Claims:	1. A pharmaceutical composition comprising a microcapsule comprising a core encapsulated by a shell, wherein said core comprises tretinoin or pharmaceutically acceptable salt thereof in a solid form and wherein the microencapsulation efficiency of the tretinoin or pharmaceutically acceptable salt thereof is at least 90%. 2. The pharmaceutical composition according to claim 1, wherein said tretinoin or pharmaceutically acceptable salt thereof is at a concentration of above 14% w/w within the core. 3. The pharmaceutical composition according to claim 1, wherein after two weeks storage at 40° C. and 75% relative humidity a concentration of all-trans 5,6-epoxy retinoic acid is less than 1% by weight of the initial tretinoin amount prior to storage. 4. The pharmaceutical composition according to claim 1, wherein the composition comprises tretinoin or a pharmaceutically acceptable salt thereof in an amount of about 0.1% by weight of said composition and the composition further comprises microcapsules comprising benzoyl peroxide, wherein the benzoyl peroxide is in an amount of about 3% by weight of said composition; and a pharmaceutically acceptable carrier or excipient, wherein the microcapsule comprising benzoyl peroxide is prepared by a process comprising: a. contacting solid benzoyl peroxide particulate matter, with a first cationic additive being a cationic surfactant, to obtain a dispersion in an aqueous medium, said particulate matter having positive charges on its surface; b. adding an aqueous solution comprising metal oxide salt to said dispersion of said particulate matter, under conditions wherein said metal oxide salt precipitates onto the surface of the particulate matter, and acidifying to thereby form a solid, water- insoluble particulate matter that has a metal oxide layer coated thereon; c. contacting, in a medium consisting of an aqueous medium, the particulate matter coated with a metal oxide layer of the preceding step with a surface adhering additive being one or both of (i) a second cationic additive being a cationic polymer and (ii) a non-ionic additive, to obtain a dispersion of said coated particulate matter having an adhering additive on the surface thereof in said aqueous medium; d. bringing the dispersion obtained in step (c) into contact with an aqueous solution of a sodium silicate, under conditions wherein said metal oxide salt precipitates onto the surface of said coated particulate matter, and acidifying to thereby form a solid, water-insoluble particulate matter that has a further metal oxide layer coated thereon; e. repeating steps (c) and (d) between 3-50 times at a temperature of between 28° C. to 40° C.; and f. optionally, after completion of step (e), aging the dispersion to obtain said encapsulated benzoyl peroxide. 5. The pharmaceutical composition according to claim 4, wherein said tretinoin or pharmaceutically acceptable salt thereof is at a concentration of above 14% w/w within the core. 6. The pharmaceutical composition according to claim 4, wherein the tretinoin or pharmaceutically acceptable salt thereof dissolution rate is between 5% to 35% weight/h as measured in a medium of 30%:70% V/V mixture of water:isopropyl alcohol at 32° C. and wherein the BPO dissolution rate is between 10% to 60% weight/h as measured in a medium of 55%:45% mixture of water:acetonitrile at ambient temperature. 7. The pharmaceutical composition according to claim 1, wherein the composition comprises tretinoin or a pharmaceutically acceptable salt thereof in an amount of about 0.1% by weight of said composition and the composition further comprises microcapsules comprising benzoyl peroxide, wherein the benzoyl peroxide is in an amount of about 3% by weight of said composition. 8. A method for treating a skin disease, disorder or condition in a subject in need thereof, said method comprising topically administering to said subject a pharmaceutical composition according to claim 1, wherein said skin disease, disorder or condition is selected from the group consisting of acne, psoriasis, seborrhea, contact dermatitis, rosacea and a combination thereof. 9. A method for treating a skin disease, disorder or condition in a subject in need thereof, said method comprising topically administering to said subject a pharmaceutical composition according to claim 4, wherein said skin disease, disorder or condition is selected from the group consisting of acne, psoriasis, seborrhea, contact dermatitis, rosacea and a combination thereof.