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Last Updated: December 16, 2025

Claims for Patent: 12,128,039

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Summary for Patent: 12,128,039

Title:	Processes for preparing quinoline compounds and pharmaceutical compositions containing such compounds
Abstract:	The present invention is directed to processes for making and compositions containing quinolines such as formula I or pharmaceutically acceptable salts thereof wherein: X1 is H, Br, CI, or X2 is H, Br, CI, or n1 is 1-2; and n2 is 1-2.
Inventor(s):	Jo Ann Wilson, Khalid Shah
Assignee:	Exelixis Inc
Application Number:	US18/436,836
Patent Litigation and PTAB cases:	See patent lawsuits and PTAB cases for patent 12,128,039
Patent Claims:	1. A pharmaceutical composition for oral administration comprising Compound IB: and a pharmaceutically acceptable carrier, wherein the pharmaceutical composition is a tablet or a capsule, and wherein the pharmaceutical composition contains 100 ppm or less of 6,7-dimethoxy-quinoline-4-ol. 2. The pharmaceutical composition of claim 1, wherein the pharmaceutical composition contains 50 ppm or less of 6,7-dimethoxy-quinoline-4-ol. 3. The pharmaceutical composition of claim 2, wherein the pharmaceutical composition contains 25 ppm or less of 6,7-dimethoxy-quinoline-4-ol. 4. The pharmaceutical composition of claim 3, wherein the pharmaceutical composition contains 10 ppm or less of 6,7-dimethoxy-quinoline-4-ol. 5. The pharmaceutical composition of claim 4, wherein the pharmaceutical composition contains 5 ppm or less of 6,7-dimethoxy-quinoline-4-ol. 6. A method of treating cancer, comprising administering to a subject in need thereof a pharmaceutical composition comprising Compound IB: and a pharmaceutically acceptable carrier, wherein the pharmaceutical composition is a tablet or a capsule, and wherein the pharmaceutical composition contains 100 ppm or less of 6,7-dimethoxy-quinoline-4-ol. 7. The method of claim 6, wherein the pharmaceutical composition contains 50 ppm or less of 6,7-dimethoxy-quinoline-4-ol. 8. The method of claim 7, wherein the pharmaceutical composition contains 25 ppm or less of 6,7-dimethoxy-quinoline-4-ol. 9. The method of claim 8, wherein the pharmaceutical composition contains 10 ppm or less of 6,7-dimethoxy-quinoline-4-ol. 10. The method of claim 9, wherein the pharmaceutical composition contains 5 ppm or less of 6,7-dimethoxy-quinoline-4-ol. 11. The method of claim 6, wherein the cancer is renal cancer. 12. The method of claim 6, wherein the cancer is prostate cancer. 13. The method of claim 6, wherein the cancer is hepatocellular carcinoma. 14. The method of claim 7, wherein the cancer is renal cancer. 15. The method of claim 7, wherein the cancer is prostate cancer. 16. The method of claim 7, wherein the cancer is hepatocellular carcinoma. 17. The method of claim 8, wherein the cancer is renal cancer. 18. The method of claim 8, wherein the cancer is prostate cancer. 19. The method of claim 8, wherein the cancer is hepatocellular carcinoma. 20. The method of claim 9, wherein the cancer is renal cancer. 21. The method of claim 9, wherein the cancer is prostate cancer. 22. The method of claim 9, wherein the cancer is hepatocellular carcinoma.

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