Claims for Patent: 12,102,754

Summary for Patent: 12,102,754

Title:	Intranasal delivery devices
Abstract:	The present disclosure provides devices for delivery of powder formulations and methods of manufacture and use of such devices.
Inventor(s):	Shunji Haruta
Assignee:	Shin Nippon Biomedical Laboratories Ltd
Application Number:	US18/298,137
Patent Claims:	1. A device for delivering a therapeutic formulation, wherein said device comprises: a pump, a reservoir containing said therapeutic formulation, a retainer, and a valve comprising a surface groove, wherein when said pump is activated, air from said pump flows by said retainer, and through said surface groove, thereby generating a vortex in said reservoir when said device is activated; and wherein said valve is stationary during activation of said pump. 2. The device of claim 1, wherein said therapeutic formulation comprises a powder therapeutic formulation. 3. The device of claim 2, wherein said powder therapeutic formulation comprises a migraine medication. 4. The device of claim 3, wherein said migraine medication comprises dihydroergotamine or a pharmaceutically acceptable salt thereof. 5. The device of claim 4, wherein said pharmaceutically acceptable salt thereof of is dihydroergotamine mesylate. 6. The device of claim 1, wherein the retainer contacts the valve. 7. The device of claim 6, wherein said retainer comprises a tray to trap the therapeutic formulation fallen from said reservoir. 8. The device of claim 1, wherein said device further comprises an air-intake that allows outside air to enter the pump. 9. The device of claim 8, wherein said air-intake comprises two air-intake holes. 10. The device of claim 6, wherein said retainer comprises an air-intake that allows outside air to enter the pump. 11. The device of claim 8, wherein said air-intake prevents said therapeutic formulation from entering said pump after said device is activated. 12. The device of claim 1, wherein said pump is a manual air pump. 13. The device of claim 1, wherein said valve is further immobilized prior to activation of said pump. 14. The device of claim 1, wherein said device comprises 3 to 20 surface grooves. 15. The device of claim 1, wherein said surface groove is diagonal to a major axis of said device. 16. The device of claim 1, wherein said valve comprises a conical top section. 17. The device of claim 16, wherein said conical top section is connected to a first shelf. 18. The device of claim 17, wherein said first shelf is connected to a first cylindrical section of the valve. 19. The device of claim 18, wherein said first cylindrical section is connected to a second shelf. 20. The device of claim 19, wherein said surface groove is on said second shelf. 21. The device of claim 2, wherein said powder therapeutic formulation comprises an antiparkinsonian agent.