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Last Updated: December 16, 2025

Claims for Patent: 12,064,434

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Summary for Patent: 12,064,434

Title:	Ribociclib tablet
Abstract:	The present disclosure is directed to oral tablet of ribociclib including its salt(s). One embodiment of the present disclosure is directed to tablet of ribociclib with high drug load with an immediate release profile. One embodiment of the present disclosure is directed to coated tablet of ribociclib. Another embodiment of the present disclosure is directed to coated tablet of ribociclib where the coating is an advanced moisture barrier coating (e.g., Opadry® amb II coating where the coating is PVA based).
Inventor(s):	Rui Costa, Arnaud Grandeury, Bindhumadhavan GURURAJAN
Assignee:	Novartis Pharmaceuticals Corp
Application Number:	US17/805,956
Patent Claims:	1. A coated pharmaceutical oral tablet comprising ribociclib succinate, the coated pharmaceutical oral tablet comprising a tablet core and a coating, wherein the % of ribociclib succinate (w/w) is at least 50% of the tablet core, and the coating is a polyvinyl alcohol (PVA)-based advanced moisture barrier coating. 2. The tablet of claim 1, wherein the coating contains 45.52% PVA, 32% iron oxide, 20% talc, 2% lecithin (soya) and 0.48% xanthan gum. 3. The tablet of claim 1, wherein the % of ribociclib succinate (w/w) is at least 55% of the tablet core. 4. The tablet of claim 1, wherein the % of ribociclib succinate (w/w) is at about 55% to 65% of the tablet core. 5. The tablet of claim 1, wherein the % of ribociclib (w/w) is at about 60% of the tablet core. 6. The tablet of claim 1, wherein the tablet core has an inner phase comprising ribociclib succinate and an outer phase.

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