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Last Updated: March 25, 2026

Claims for Patent: 12,059,423

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Summary for Patent: 12,059,423

Title:	Meloxicam composition, pharmaceutical preparation and preparation method and use thereof
Abstract:	The disclosure is related to a meloxicam compositions, pharmaceutical preparations, preparation methods and use thereof. In one aspect of the invention, meloxicam compositions contain meloxicam and cosolvents. The cosolvents are mixed solvents including water and organic solvents. In another aspect of the invention, other compositions contain meloxicam, solvents, and pH regulators. The pH regulators include at least citric acid. The pharmaceutical compositions significantly enhance the solubility of meloxicam in liquid pharmaceutical preparations as well as stability. The meloxicam compositions can be directly used for intravenous injection administration to quickly reach effective therapeutic concentrations for post-operative analgesia.
Inventor(s):	Qingsong WANG, Wenliang Zhou, Qu WU, Limin Zou
Assignee:	Nanjing Delova Biotech Co Ltd
Application Number:	US17/044,767
Patent Claims:	1. A meloxicam composition, consisting of meloxicam, water, and an organic solvent selected from polyethylene glycol 200, polyethylene glycol 300, polyethylene glycol 400, polyethylene glycol 600, and mixtures thereof, wherein water and the organic solvent form a cosolvent having a concentration of the organic solvent of 5% to 80%, a ratio of the mass of meloxicam to the volume of the cosolvent is 5 mg/mL to 35 mg/mL, a pH of the composition is in the range of 6.5 to 10.0. 2. A liquid pharmaceutical preparation, comprising the composition according to claim 1. 3. The liquid pharmaceutical preparation according to claim 2 in the form of an intravenous injection. 4. The composition according to claim 1, wherein the organic solvent is polyethylene glycol 300, polyethylene glycol 400, or polyethylene glycol 600. 5. The composition according to claim 1, wherein the pH of the composition is in the range of 6.8 to 10.0. 6. The composition according to claim 1, wherein the pH of the composition is in the range of 7.2 to 10.0. 7. The composition according to claim 1, wherein the pH of the composition is in the range of 7.2 to 9.0. 8. The composition according to claim 1, wherein the concentration of the organic solvent in the cosolvent is in the range of 10% to 60%. 9. The composition according to claim 1, wherein the concentration of the organic solvent in the cosolvent is in the range of 15% to 50%. 10. The composition according to claim 1, wherein the concentration of the organic solvent in the cosolvent is in the range of 20% to 40%. 11. The composition according to claim 1, wherein the ratio of the mass of meloxicam to the volume of the cosolvent is 10 mg/mL to 30 mg/mL. 12. The composition according to claim 1, wherein the ratio of the mass of meloxicam to the volume of the cosolvent is 15 mg/mL to 30 mg/mL.

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