Claims for Patent: 11,951,214

Summary for Patent: 11,951,214

Title:	Capsule formulations
Abstract:	The present disclosure provides solid solution capsule formulations of Compound 1and methods of making the same. Also provided herein are methods of treating individuals suffering from or susceptible to a disease or disorder involving pathologic activation of C5a receptors by administering an effective amount of one or more solid solution capsules comprising Compound 1. Further provided herein are singe unit dosage capsules comprising certain amounts of Compound 1, and kits comprising a solid solution capsule comprising Compound 1.
Inventor(s):	Manmohan Reddy Leleti, Jay P. Powers
Assignee:	Chemocentryx Inc
Application Number:	US17/545,878
Patent Litigation and PTAB cases:	See patent lawsuits and PTAB cases for patent 11,951,214
Patent Claims:	1. A solid solution capsule formulation comprising Compound 1 as a free base, in its neutral form, or in the form of a pharmaceutically acceptable salt and a vehicle comprising at least one non-ionic surfactant selected from the group consisting of macrogol-40-glycerol hydroxystearate, macrogolglycerol ricinoleate, and macrogol-15-hydroxystearate, and at least one water-soluble solubilizer selected from the group consisting of PEG-1500, PEG-1540, PEG-2000, PEG-3000, PEG-3350, PEG-4000, PEG-6000, PEG-8000, wherein Compound 1 comprises about 1 to 3% by weight of the total fill weight of said solid solution capsule formulation, the vehicle comprises about 97 to 99% by weight of the total fill weight of said solid solution capsule formulation, and the total weight of the vehicle comprises a 45:55 to 55:45 ratio of the at least one non-ionic surfactant to the at least one water-soluble solubilizer. 2. The solid solution capsule formulation of claim 1 wherein the vehicle comprises about 98% by weight of the total fill weight of said solid solution capsule formulation. 3. The solid solution capsule formulation of claim 1, comprising about 2% of Compound 1 by weight of the total fill weight of said solid solution capsule formulation. 4. The solid solution capsule formulation of claim 1, wherein the total weight of the vehicle comprises about a 50:50 ratio of the at least one non-ionic surfactant to the at least one water-soluble solubilizer. 5. The solid solution capsule formulation of claim 1, wherein the at least one non-ionic surfactant is macrogol-40-glycerol hydroxystearate or macrogolglycerol ricinoleate. 6. The solid solution capsule formulation of claim 1, wherein the at least one non-ionic surfactant is macrogol-40-glycerol hydroxystearate. 7. The solid solution capsule formulation of claim 1, wherein the at least one water-soluble solubilizer is selected from the group consisting of PEG-1540, PEG-2000, PEG-3000, PEG-3350, PEG-4000, PEG-6000. 8. The solid solution capsule formulation of claim 1, wherein the at least one water-soluble solubilizer is PEG-4000. 9. The solid solution capsule formulation of claim 1, wherein the at least one non-ionic surfactant is macrogol-40-glycerol hydroxystearate and the at least one water-soluble solubilizer is PEG-4000. 10. The solid solution capsule formulation of claim 1, wherein the total fill weight of said solid solution capsule is from about 130 mg to 900 mg. 11. The solid solution capsule formulation of claim 1, wherein the total fill weight of said solid solution capsule is about 500 mg. 12. The solid solution capsule formulation of claim 1, wherein the capsule size is #0. 13. The solid solution capsule formulation of claim 1, wherein the capsule is a hard capsule. 14. The solid solution capsule formulation of claim 2, comprising about 2% of Compound 1 by weight of the total fill weight of said solid solution capsule formulation. 15. The solid solution capsule formulation of claim 14, wherein the total weight of the vehicle comprises about a 50:50 ratio of the at least one non-ionic surfactant to the at least one water-soluble solubilizer. 16. The solid solution capsule formulation of claim 15, wherein the at least one non-ionic surfactant is macrogol-40-glycerol hydroxystearate. 17. The solid solution capsule formulation of claim 16, wherein the at least one water-soluble solubilizer is PEG-4000. 18. The solid solution capsule formulation of claim 17, wherein the total fill weight of said solid solution capsule is about 500 mg.