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Last Updated: December 16, 2025

Claims for Patent: 11,857,542

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Summary for Patent: 11,857,542

Title:	Treatment of migraine
Abstract:	The present disclosure provides methods for the acute treatment of migraine with or without aura, comprising the administration of ubrogepant. In particular, the present disclosure provides methods for the acute treatment of migraine in patients having hepatic impairment; in patients with renal impairment; and in patients concurrently taking CYP3A4 modulators or BCRP and/or P-gp only inhibitors.
Inventor(s):	Joel M. Trugman, Ramesh BOINPALLY, Abhijeet Jakate, Michelle Finnegan
Assignee:	Allergan Pharmaceuticals International Ltd
Application Number:	US18/210,719
Patent Litigation and PTAB cases:	See patent lawsuits and PTAB cases for patent 11,857,542
Patent Claims:	1. A method for the acute treatment of migraine with or without aura in a patient with severe renal impairment, the method comprising orally administering 50 mg ubrogepant to the patient, wherein the patient's estimated creatinine clearance as determined using the Cockcroft-Gault equation is 15-29 mL/min, and wherein the patient's migraine is safely and effectively treated. 2. The method of claim 1, comprising orally administering to the patient a second dose of 50 mg of ubrogepant at least 2 hours after the administration of the initial 50 mg of ubrogepant. 3. The method of claim 2, wherein the second dose is administered to the patient between 2 and 24 hours after the administration of the initial 50 mg of ubrogepant. 4. The method of claim 1, wherein the patient achieves freedom from at least one migraine symptom within 2 hours after the administration of said ubrogepant.

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