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Last Updated: December 16, 2025

Claims for Patent: 11,839,689

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Summary for Patent: 11,839,689

Title:	Formulations of enzalutamide
Abstract:	This disclosure provides formulations of enzalutamide and their use for treating hyperproliferative disorders.
Inventor(s):	Douglas Alan Lorenz, Sanjay Konagurthu, Randy J. Wald, Jason A. Everett, Sheila Matz, Yuuki Takaishi, Toshiro Sakai, Ryousuke Irie, Shinsuke Oba, Hiroyasu Toyota, Koji Nishimura, Atsushi Kanbayashi
Assignee:	Astellas Pharma Inc , Medivation Prostate Therapeutics LLC
Application Number:	US17/985,235
Patent Claims:	1. A pharmaceutical composition comprising a solid dispersion consisting essentially of amorphous enzalutamide and hydroxypropyl methylcellulose acetate succinate. 2. The pharmaceutical composition according to claim 1, wherein the solid dispersion is a spray-dried dispersion. 3. A pharmaceutical composition comprising a solid dispersion consisting essentially of amorphous enzalutamide and hydroxypropyl methylcellulose acetate succinate, wherein the solid dispersion is a spray-dried dispersion, and wherein the amorphous enzalutamide remains amorphous following storage of the spray-dried dispersion at 40° C. and 75% relative humidity for 1 month. 4. A tablet comprising the pharmaceutical composition according to claim 2. 5. The tablet according to claim 4, wherein the amount of amorphous enzalutamide is 80 mg. 6. The tablet according to claim 4 further comprising croscarmellose sodium and magnesium stearate. 7. A tablet comprising a pharmaceutical composition comprising: a solid dispersion consisting essentially of amorphous enzalutamide and hydroxypropyl methylcellulose acetate succinate, wherein the solid dispersion is a spray-dried dispersion,; and croscarmellose sodium and magnesium stearate, wherein the croscarmellose sodium is 6% to 10% of the total tablet weight.

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