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Last Updated: December 15, 2025

Claims for Patent: 11,839,487

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Summary for Patent: 11,839,487

Title:	Ophthalmic drug delivery
Abstract:	The present invention includes and provides a method of delivering a medicament to an eye of a subject in need thereof a solution, the method comprising: (a) providing droplets containing the medicament with a specified average size and average initial ejecting velocity; and (b) delivering the medicament to the eye, where the droplets deliver a percentage of the ejected mass of the droplets to the eye.
Inventor(s):	Bernard L. Ballou, JR., Mark Packer, Russell John Mumper, Tsontcho Ianchulev
Assignee:	Eyenovia Inc
Application Number:	US17/849,425
Patent Claims:	1. A method of delivering droplets to a surface of an eye of a subject in need thereof, the method comprising: (a) generating the droplets via a piezoelectric actuated ejection device, wherein: (i) the droplets: (ia) comprise an ophthalmic composition comprising tropicamide and phenylephrine hydrochloride; (ib) have a total volume of 5 μl to 10 μl; (ic) have a an average droplet size from 30 microns to 100 microns; and (id) have an average initial electing velocity from 1 m/s to about 5/ms; and (ii) the piezoelectric actuated ejection device comprises a housing; a reservoir containing the ophthalmic composition disposed within the housing; and an ejector mechanism fluidly coupled to the reservoir, the ejector mechanism comprising an ejector plate comprising a plurality of openings formed through its thickness, and a piezoelectric actuator coupled to the ejector plate, the actuator being operable to oscillate the ejector plate at a frequency to generate the droplets from the composition upon actuation; and (b) delivering the droplets to the surface of the eye of the subject. 2. The method of claim 1, wherein the ophthalmic composition comprises about 2.5% phenylephrine hydrochloride and about 1% tropicamide. 3. The method of claim 2, wherein the ophthalmic composition further comprises a preservative. 4. The method of claim 3, wherein the ophthalmic composition comprises 0.1% or less of the preservative. 5. The method of claim 1, wherein the ophthalmic composition is a solution. 6. The method of claim 2, wherein the ophthalmic composition is a solution.

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