Claims for Patent: 11,813,255

Summary for Patent: 11,813,255

Title:	Methods of treating Fabry patients having renal impairment
Abstract:	Provided are methods for treatment of Fabry disease in patients having HEK assay amenable mutations in α-galactosidase A. Certain methods comprise administering migalastat or a salt thereof every other day, such as administering about 150 mg of migalastat hydrochloride every other day.
Inventor(s):	Jeff Castelli, Elfrida Benjamin
Assignee:	Amicus Therapeutics Inc
Application Number:	US18/069,716
Patent Litigation and PTAB cases:	See patent lawsuits and PTAB cases for patent 11,813,255
Patent Claims:	1. A method of treating Fabry disease, the method comprising administering migalastat to a patient in need thereof, wherein the patient has an α-galactosidase A protein comprising a HEK assay amenable mutation selected from the group consisting of A13T, D322N and M421V. 2. The method of claim 1, wherein the mutation is A13T. 3. The method of claim 1, wherein the mutation is D322N. 4. The method of claim 1, wherein the mutation is M421V. 5. The method of claim 1, wherein the patient has a Fabry disease-causing mutation. 6. The method of claim 1, wherein the migalastat or salt thereof is administered to the patient every other day. 7. The method of claim 1, wherein the patient is administered about 123 to about 300 mg of the migalastat or salt thereof every other day. 8. The method of claim 1, wherein the patient is administered about 150 mg of the migalastat or salt thereof every other day. 9. The method of claim 1, wherein the patient is administered about 150 mg of migalastat hydrochloride every other day. 10. The method of claim 1, wherein the patient is male. 11. The method of claim 1, wherein the patient is female. 12. The method of claim 1, wherein the patient has renal impairment. 13. The method of claim 1, wherein the patient has mild or moderate renal impairment. 14. The method of claim 1, wherein the patient is an enzyme replacement therapy (ERT)-experienced patient. 15. The method of claim 1, wherein the patient is an enzyme replacement therapy (ERT)-experienced patient with renal impairment. 16. The method of claim 1, wherein the patient is an enzyme replacement therapy (ERT)-naïve patient. 17. The method of claim 1, wherein the patient has a proteinuria level of less than 100 mg/24 hr prior to initiating the administration of the migalastat or salt thereof. 18. The method of claim 1, wherein the patient has a proteinuria level of 100 to 1,000 mg/24 hr prior to initiating the administration of the migalastat or salt thereof. 19. The method of claim 1, wherein the patient has a proteinuria level of greater than 1,000 mg/24 hr prior to initiating the administration of the migalastat or salt thereof. 20. The method of claim 1, wherein the migalastat or salt thereof is administered orally. 21. The method of claim 20, wherein the migalastat or salt thereof is in a solid dosage form. 22. The method of claim 21, wherein the solid dosage form comprises a capsule. 23. The method of claim 1, wherein the migalastat is administered as a pharmaceutically acceptable salt. 24. The method of claim 1, wherein the patient is orally administered about 150 mg of migalastat hydrochloride every other day and wherein the administration is effective to reduce globotriaosylceramide (GL-3) accumulated in an organ of the patient. 25. The method of claim 1, wherein the patient is orally administered about 150 mg of migalastat hydrochloride every other day and wherein the administration is effective to reduce plasma globotriaosylsphingosine (lyso-Gb3) in the patient. 26. The method of claim 1, wherein the patient is orally administered about 150 mg of migalastat hydrochloride every other day and wherein the administration is effective to increase white blood cell (WBC) α-galactosidase A activity in the patient. 27. The method of claim 1, wherein the patient is orally administered about 150 mg of migalastat hydrochloride every other day and wherein the administration is effective to reduce left ventricular mass index (LVMi) in the patient. 28. The method of claim 1, wherein the patient is orally administered about 150 mg of migalastat hydrochloride every other day and wherein the administration is effective to stabilize renal function in the patient. 29. The method of claim 1, wherein the patient is orally administered about 150 mg of migalastat hydrochloride every other day and wherein the administration is effective to (i) reduce globotriaosylceramide (GL-3) accumulated in an organ of the patient, (ii) reduce plasma globotriaosylsphingosine (lyso-Gb3) in the patient, (iii) increase white blood cell (WBC) α-galactosidase A activity in the patient, (iv) reduce left ventricular mass index (LVMi) in the patient, and (v) stabilize renal function in the patient.