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Last Updated: December 18, 2025

Claims for Patent: 11,801,237

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Summary for Patent: 11,801,237

Title:	Amorphous kinase inhibitor formulations and methods of use thereof
Abstract:	Provided herein is an amorphous compound represented by Formula (I): and compositions thereof, which are useful in the treatment of disorders related to the activity of the c-KIT and PDGFRα kinases, and oncogenic forms thereof.
Inventor(s):	Michael D. Kaufman, Scott Bone, Corey Bloom, Fred Jordan
Assignee:	Deciphera Pharmaceuticals LLC
Application Number:	US18/314,348
Patent Claims:	1. A pharmaceutically acceptable tablet for orally delivering 50 mg of a compound represented by Formula (I): the tablet comprising: (i) a solid dispersion having 50 mg of the compound wherein the compound is present in amorphous form and 150 mg hydroxypropyl methyl cellulose acetate succinate; (ii) 179 mg microcrystalline cellulose; (iii) 179 mg lactose or a hydrate thereof; (iv) 30 mg crospovidone; (v) 6 mg of silicon dioxide; and (vi) 6 mg of magnesium stearate. 2. A method of treating a gastrointestinal stromal tumor in a patient in need thereof, comprising orally administering to the patient: a pharmaceutically acceptable tablet for orally delivering 50 mg of a compound represented by Formula (I): the tablet comprising: (i) a solid dispersion having 50 mg of the compound wherein the compound is present in amorphous form and 150 mg hydroxypropyl methyl cellulose acetate succinate; (ii) 179 mg microcrystalline cellulose; (iii) 179 mg lactose or a hydrate thereof; (iv) 30 mg crospovidone; (v) 6 mg of silicon dioxide; and (vi) 6 mg of magnesium stearate.

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