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Last Updated: December 16, 2025

Claims for Patent: 11,793,795

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Summary for Patent: 11,793,795

Title:	Compositions of 1-(4-bromo-5-(1-ethyl-7-(methylamino)-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-2-fluorophenyl)-3-phenylurea
Abstract:	Provided herein are low impurity compositions comprising a compound represented by Formula (I):which are useful in the treatment of disorders related to the activity of the c-KIT and PDGFRα kinases, and oncogenic forms thereof.
Inventor(s):	Michael D. Kaufman, Scott Bone, Corey Bloom, Fred Jordan
Assignee:	Deciphera Pharmaceuticals LLC
Application Number:	US18/178,789
Patent Claims:	1. A pharmaceutical composition for orally delivering 50 mg of a compound represented by Formula (I): the pharmaceutical composition comprising: a solid dispersion comprising: (a) 50 mg of the compound wherein the compound is present in amorphous form; and (b) hydroxypropyl methyl cellulose acetate succinate; and aniline in an amount equal to or less than about 5% by weight based on the total weight of the pharmaceutical composition. 2. The pharmaceutical composition of claim 1, comprising aniline in an amount equal to or less than about 3% by weight based on the total weight of the pharmaceutical composition. 3. The pharmaceutical composition of claim 1, comprising aniline in an amount equal to or less than about 2% by weight based on the total weight of the pharmaceutical composition. 4. The pharmaceutical composition of claim 1, comprising aniline in an amount equal to or less than about 1% by weight based on the total weight of the pharmaceutical composition. 5. The pharmaceutical composition of claim 1, comprising aniline in an amount equal to or less than about 0.5% by weight based on the total weight of the pharmaceutical composition. 6. A pharmaceutical composition comprising: a solid dispersion comprising: (a) a compound represented by Formula (I): wherein the compound is present in amorphous form; and (b) hydroxypropyl methyl cellulose acetate succinate; and aniline in an amount equal to or less than about 5% by weight based on the total weight of the pharmaceutical composition. 7. The pharmaceutical composition of claim 6, comprising aniline in an amount equal to or less than about 3% by weight based on the total weight of the pharmaceutical composition. 8. The pharmaceutical composition of claim 6, comprising aniline in an amount equal to or less than about 2% by weight based on the total weight of the pharmaceutical composition. 9. The pharmaceutical composition of claim 6, comprising aniline in an amount equal to or less than about 1% by weight based on the total weight of the pharmaceutical composition. 10. The pharmaceutical composition of claim 6, comprising aniline in an amount equal to or less than about 0.5% by weight based on the total weight of the pharmaceutical composition.

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