Claims for Patent: 11,696,902

Summary for Patent: 11,696,902

Title:	Method of initiating and escalating sotalol hydrochloride dosing
Abstract:	This disclosure provides a method of safely and rapidly initiating or escalating oral sotalol therapy by administering an intravenous dosage of sotalol followed by oral sotalol twice daily.
Inventor(s):	John Somberg, Brandon Ira Kashfian, Janos Molnar
Assignee:	Altathera Pharmaceuticals LLC
Application Number:	US16/693,310
Patent Claims:	1. A method of initiating oral sotalol hydrochloride therapy comprising: identifying a subject as naïve to sotalol, having symptomatic atrial fibrillation or atrial flutter, and currently in sinus rhythm; administering to the subject a single intravenous (IV) dosage of sotalol hydrochloride, over a period of 1 hour, wherein the single IV dosage comprises an amount of sotalol hydrochloride in the range of 116-141 mg; after completion of the single IV dosage of sotalol hydrochloride, administering a first oral dosage of sotalol hydrochloride in the amount of 120 mg. 2. The method of claim 1, wherein the first oral dosage is administered starting 4-6 hours after completion of the IV dosage. 3. The method of claim 2, further comprising administering a second oral dosage, wherein the second oral dosage is administered 12 hours after the first oral dosage. 4. The method of claim 3, further comprising administering one or more subsequent oral dosage at a 12-hour interval from the second oral dosage. 5. The method of claim 1, wherein the single IV dosage comprises an amount of sotalol hydrochloride in the range of 121-141 mg.