Claims for Patent: 11,680,050

Summary for Patent: 11,680,050

Title:	Crystalline forms of ozanimod and ozanimod hydrochloride, and processes for preparation thereof
Abstract:	The present disclosure is directed to novel crystalline forms of ozanimod and ozanimod hydrochloride, as well as preparation method thereof. Said crystalline forms of ozanimod and ozanimod hydrochloride can be used for treating autoimmune diseases, particularly used for preparing drugs for treating multiple sclerosis and ulcerative colitis. The crystalline forms of the present disclosure have one or more advantages in solubility, melting point, stability, dissolution, bioavailability and processability and provide new and better choices for the preparation of ozanimod drug product, and are very valuable for drug development.
Inventor(s):	Minhua Chen, Xiaoyu Zhang, Yanfeng Zhang, Chaohui YANG, Xiaoting ZHAI, Kaiqiang YAN
Assignee:	Receptos LLC
Application Number:	US16/748,303
Patent Litigation and PTAB cases:	See patent lawsuits and PTAB cases for patent 11,680,050
Patent Claims:	1. A crystalline Form CS1 of ozanimod hydrochloride, wherein the X-ray powder diffraction pattern shows characteristic peaks at 2theta values of 26.1°±0.20°, 24.4°±0.20° and 20.1°±0.20° using CuKα radiation. 2. The crystalline Form CS1 of ozanimod hydrochloride according to claim 1, wherein the X-ray powder diffraction pattern shows 1 or 2 or 3 characteristic peaks at 2theta values of 3.9°±0.20°, 21.1°±0.20° and 7.9°±0.20° using CuKα radiation. 3. The crystalline Form CS1 of ozanimod hydrochloride according to claim 1, wherein the X-ray powder diffraction pattern shows 1 or 2 or 3 characteristic peaks at 2theta values of 11.9°±0.20°, 19.6°±0.20° and 13.8°±0.20° using CuKα radiation. 4. A process for preparing crystalline Form CS1 of ozanimod hydrochloride according to claim 1, wherein the process comprises method 1) or method 2) or method 3) or method 4) or method 5), 1) adding ozanimod hydrochloride into an ether and stirring at 4-50° C., filtering and drying to obtain a white solid of Form CS1 of ozanimod hydrochloride; said stirring time is at least 0.5 hour; or 2) dissolving ozanimod hydrochloride into a mixture of an alcohol and an ester, evaporating at room temperature to obtain a white solid of Form CS1 of ozanimod hydrochloride; said evaporating time is at least 0.5 day; or 3) dissolving ozanimod hydrochloride into a solvent selected from an amide or a mixture of solvents thereof, then placing the solution in a system containing an antisolvent of ozanimod hydrochloride for liquid vapor diffusion at room temperature, filtering and drying to obtain a white solid of Form CS1 of ozanimod hydrochloride; said diffusion time is at least 1 day; or 4) dissolving ozanimod hydrochloride into a mixture of an alcohol and water to form a supersaturated solution, ozanimod hydrochloride is fully dissolved at 25-80° C. and then filtering, cooling the filtrate for precipitation, filtering and drying to obtain a white solid of Form CS1 of ozanimod hydrochloride; or 5) dissolving ozanimod hydrochloride into an alcohol in a concentration of 12 mg/mL to form an alcohol solution, filtering and evaporating the alcohol solution at room temperature for 1 week to obtain a white solid of Form CS1 of ozanimod hydrochloride. 5. A pharmaceutical composition, wherein said pharmaceutical composition comprises a therapeutically effective amount of crystalline Form CS1 of ozanimod hydrochloride according to claim 1 and a pharmaceutically acceptable carrier, a diluent or an excipient. 6. A method of treating ulcerative colitis, comprising administering to a patient in need thereof a therapeutically effective amount of crystalline Form CS1 of ozanimod hydrochloride according to claim 1. 7. A method of treating multiple sclerosis, comprising administering to a patient in need thereof a therapeutically effective amount of crystalline Form CS1 of ozanimod hydrochloride according to claim 1.