Claims for Patent: 11,679,115

Summary for Patent: 11,679,115

Title:	Topical compositions and methods for treating psoriasis
Abstract:	Topical pharmaceutical compositions comprise a combination of a corticosteroid a retinoid; and methods for treating psoriasis with same.
Inventor(s):	Gordon J. Dow, Radhakrishnan Pillai, Varsha D. Bhatt
Assignee:	Bausch Health Ireland Ltd
Application Number:	US17/154,591
Patent Claims:	1. A topical pharmaceutical composition for treating psoriasis, the composition comprising: (a) halobetasol propionate at a concentration of about 0.01% by weight of the composition; (b) tazarotene at a concentration of about 0.045% by weight of the composition; and (c) a dermatologically acceptable carrier comprising: diethyl sebacate at a concentration of about 2.5% to 3.5% by weight of the composition, a mineral oil at a concentration of about 7.5% to 8.5% by weight of the composition, carbomer copolymer type B at a concentration of about 0.3% to 0.5% by weight of the composition, carbomer homopolymer type A at a concentration of about 0.5% to about 0.7% by weight of the composition, and purified water. 2. The topical pharmaceutical composition of claim 1, further comprising one or more components selected from the group consisting of a surfactant, a humectant, one or more antimicrobial preservatives, a chelating agent, and a pH-adjusting agent. 3. The topical pharmaceutical composition of claim 2, wherein the surfactant is sorbitan monooleate, which is present at a concentration of about 0.05% to 0.2% by weight of the composition. 4. The topical pharmaceutical composition of claim 2, wherein the humectant is sorbitol solution (70%), which is present at a concentration of about 10% to about 11% by weight of the composition. 5. The topical pharmaceutical composition of claim 2, wherein the antimicrobial preservatives consist of methyl paraben, which is present at a concentration of about 0.1% to about 0.2% by weight of the composition, and propyl paraben, which is present at a concentration of about 0.02% to about 0.04% by weight of the composition. 6. The topical pharmaceutical composition of claim 2, wherein the chelating agent is edetate disodium dihydrate, which is present at a concentration of about 0.03% to about 0.06% by weight of the composition. 7. The topical pharmaceutical composition of claim 2, wherein the pH adjusting agent is sodium hydroxide, which is present in an amount to provide a pH of 5.5±0.5. 8. The topical pharmaceutical composition of claim 1, further comprising a surfactant, a humectant, one or more antimicrobial preservatives, a chelating agent, and a pH-adjusting agent. 9. The topical pharmaceutical composition of claim 8, wherein the surfactant is sorbitan monooleate, which is present at a concentration of about 0.05% to 0.2% by weight of the composition. 10. The topical pharmaceutical composition of claim 9, wherein the humectant is sorbitol solution (70%), which is present at a concentration of about 10% to about 11% by weight of the composition. 11. The topical pharmaceutical composition of claim 10, wherein the antimicrobial preservatives consist of methyl paraben, which is present at a concentration of about 0.1% to about 0.2% by weight of the composition, and propyl paraben, which is present at a concentration of about 0.02% to about 0.04% by weight of the composition. 12. The topical pharmaceutical composition of claim 11, wherein the chelating agent is edetate disodium dihydrate, which is present at a concentration of about 0.03% to about 0.06% by weight of the composition. 13. The topical pharmaceutical composition of claim 12, wherein the pH adjusting agent is sodium hydroxide, which is present in an amount to provide a pH of 5.5±0.5. 14. The topical pharmaceutical composition of claim 8, wherein: the diethyl sebacate is present at a concentration of about 2.97% by weight of the composition, the mineral oil is light mineral oil, which is present at a concentration of about 8.03% by weight of the composition, the carbomer copolymer type B is present at a concentration of about 0.4% by weight of the composition, the carbomer homopolymer type A is present at a concentration of about 0.6% by weight of the composition, the surfactant is sorbitan monooleate, which is present at a concentration of about 0.1% by weight of the composition, the humectant is sorbitol solution (70%), which is present at a concentration of about 10.7% by weight of the composition, the antimicrobial preservatives consist of methyl paraben, which is present at a concentration of about 0.17% by weight of the composition, and propyl paraben, which is present at a concentration of about 0.03% by weight of the composition, the chelating agent is edetate disodium dihydrate, which is present at a concentration of about 0.05% by weight of the composition, and the pH adjusting agent is sodium hydroxide, which is present in an amount to provide a pH of 5.5±0.5. 15. A method of treating psoriasis, the method comprising topically applying a pharmaceutical composition according to claim 1 to an affected area of a body of a subject suffering from psoriasis, wherein the applying is carried out one or more times per day for a period of time sufficient to treat the psoriasis. 16. The method of claim 15, wherein the applying is carried out once per day for eight weeks. 17. The method of claim 15, wherein: the diethyl sebacate is present at a concentration of about 2.97% by weight of the composition, the mineral oil is light mineral oil, which is present at a concentration of about 8.03% by weight of the composition, the carbomer copolymer type B is present at a concentration of about 0.4% by weight of the composition, the carbomer homopolymer type A is present at a concentration of about 0.6% by weight of the composition, and wherein the composition further comprises: sorbitan monooleate at a concentration of about 0.1% by weight of the composition, sorbitol solution (70%), at a concentration of about 10.7% by weight of the composition, methyl paraben at a concentration of about 0.17% by weight of the composition, propyl paraben at a concentration of about 0.03% by weight of the composition, edetate disodium dihydrate at a concentration of about 0.05% by weight of the composition, and sodium hydroxide in an amount to provide a pH of 5.5±0.5.