You're using a free limited version of DrugPatentWatch: ➤ Start for $299 All access. No Commitment.

Last Updated: March 27, 2026

Claims for Patent: 11,571,478

✉ Email this page to a colleague

« Back to Dashboard

Summary for Patent: 11,571,478

Title:	Methods for photodynamic therapy
Abstract:	A method of enhancing penetration of a topical composition of 5-aminolevulinic acid (ALA) into tissue for photodynamic therapy includes topically applying ALA to a treatment area to be treated with photodynamic therapy. The method further includes, after the ALA is applied to the treatment area, covering the treatment area with a low density polyethylene barrier. The treatment area is covered with the low density polyethylene barrier prior to light treatment to minimize transepidermal water loss from the treatment area.
Inventor(s):	Scott Lundahl, Michael Guttadauro
Assignee:	Sun Pharmaceutical Industries Inc
Application Number:	US17/487,698
Patent Claims:	1. A method of enhancing penetration of a topical composition of 5-aminolevulinic acid (ALA) into tissue for photodynamic therapy, the method comprising: topically applying ALA to a treatment area to be treated with photodynamic therapy; after the ALA is applied to the treatment area, covering the treatment area with a low density polyethylene barrier prior to light treatment such that a degree of occlusion of the treatment area of at least 65% is provided; and removing the low density polyethylene barrier after 3 hours and then applying light to the treatment area. 2. The method according to claim 1, comprising covering the treatment area with the low density polyethylene barrier prior to light treatment such that a degree of occlusion of the treatment area of at least 75% is provided. 3. The method according to claim 1, comprising covering the treatment area with the low density polyethylene barrier prior to light treatment such that a degree of occlusion of the treatment area of at least 85% is provided. 4. The method according to claim 1, wherein the barrier contacts the treatment area. 5. The method according to claim 1, wherein the treatment area is covered with the barrier by conforming the barrier to the treatment area such that the barrier stays close to a surface of the treatment area. 6. The method according to claim 1, wherein the low density polyethylene barrier is held in place with an elastic net. 7. The method according to claim 1, wherein the barrier is covered with material. 8. The method according to claim 1, wherein the barrier is covered with material by placing the material over and around the barrier. 9. The method according to claim 1, wherein the low density polyethylene barrier is removed within 3 hours 18 minutes. 10. The method according to claim 1, wherein the treatment area is wet when the treatment area is covered with the low density polyethylene barrier. 11. The method according to claim 1, wherein the topical composition comprises a gel. 12. The method according to claim 1, wherein the light is red light. 13. The method according to claim 1, wherein the ALA is applied digitally. 14. The method according to claim 1, wherein the ALA is applied with a hand-held device. 15. The method according to claim 1, wherein the treatment area comprises an actinic keratosis lesion. 16. The method according to claim 1, wherein the treatment area is heated by about 2° C. prior to applying light to the treatment area. 17. A method of enhancing penetration of a topical composition of 5-aminolevulinic acid (ALA) into tissue for photodynamic therapy, the method comprising: topically applying ALA to a treatment area to be treated with photodynamic therapy; after the ALA is applied to the treatment area, covering the treatment area with a low density polyethylene barrier prior to light treatment such that a degree of occlusion of the treatment area of at least 65% is provided; and removing the low density polyethylene barrier after 3 hours and then applying light to the treatment area, wherein the treatment area is not heated prior to applying light to the treatment area. 18. A method of enhancing penetration of a topical composition of 5-aminolevulinic acid (ALA) into tissue for photodynamic therapy, the method comprising: topically applying ALA to a treatment area to be treated with photodynamic therapy; after the ALA is applied to the treatment area, covering the treatment area with a low density polyethylene barrier prior to light treatment such that a degree of occlusion of the treatment area of at least 65% is provided; and removing the low density polyethylene barrier after 3 hours and then applying light to the treatment area, wherein the barrier comprises a two layer barrier wherein a top layer provides light pressure to keep a lower layer in place.

Make Better Decisions: Try a trial or see plans & pricing

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. We do not provide individual investment advice. This service is not registered with any financial regulatory agency. The information we publish is educational only and based on our opinions plus our models. By using DrugPatentWatch you acknowledge that we do not provide personalized recommendations or advice. thinkBiotech performs no independent verification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.