Claims for Patent: 11,529,368

Summary for Patent: 11,529,368

Title:	Colonoscopy—preparation
Abstract:	The invention provides a colon cleansing solution comprising: a) 300 to 2000 mmol per litre ascorbate anion provided by ascorbic acid, one or more salts of ascorbic acid, or a mixture thereof; and h) 10 to 200 g per litre polyethylene glycol. The invention also provides methods and kits associated with, or making use of the solutions. The invention also provides a method of cleansing the colon of a subject comprising: —administering to the subject an effect amount of a first cleansing solution; and then after a time interval—administering to the subject an effective amount of a second cleansing solution, wherein the two cleansing solutions are as described in the specification.
Inventor(s):	Marc Halphen, Hans-Jurgen Gruss, Ian Cox, Alasdair Cockett, Peter Stein, Alex Ungar
Assignee:	Norgine BV
Application Number:	US17/025,531
Patent Claims:	1. A colon cleansing composition, comprising: 52.5 to 187.5 g PEG having an average molecular weight of 2500 to 4500 Da; and 3.75 to 15 g of one or more alkali metal sulphates, alkaline earth metal sulphates or a mixture thereof; wherein the composition is configured for colon cleansing in an ingestion volume of 400 to 600 ml of water; and wherein the composition is free from ascorbate components. 2. The composition of claim 1, wherein the ingestion volume is about 500 ml of water. 3. The composition of claim 1, wherein the PEG is in the range of 75 to 150 g. 4. The composition of claim 1, wherein the PEG is in the range of 90 to 112.5 g. 5. The composition of claim 1, wherein the PEG is in the amount of 100 g. 6. The composition of claim 1, wherein the one or more alkali metal sulphates, alkaline earth metal sulphates or the mixture thereof is in the range of 6 to 15 g. 7. The composition of claim 1, wherein the one or more alkali metal sulphates, alkaline earth metal sulphates or the mixture thereof is in the amount of 9 g. 8. The composition of claim 1, further comprising: 0.75 to 2.25 g sodium chloride; and 0.075 to 2.25 g potassium chloride. 9. The composition of claim 1, further comprising a sweetener wherein the sweetener is sucralose. 10. The composition of claim 1, further comprising citric acid. 11. The composition of claim 1, further comprising: 1.5 to 2.25 g sodium chloride, 0.15 to 1.5 g potassium chloride, sucralose, and citric acid; wherein: the PEG is in the amount of 100 g and the average molecular weight is 3000 to 4000 Da; and the one or more alkali metal sulphates, alkaline earth metal sulphates or the mixture thereof is in the amount of 9 g sodium sulphate. 12. The composition of claim 1, wherein the polyethylene glycol is present at a level between 77.8% and 98.0% w/w; and the sulphate component is present at a level between 2.0% and 22.2% w/w. 13. A colon cleansing solution, comprising: 130 to 250 g per liter PEG having an average molecular weight of 2500 to 4500 Da; and 15 to 20 g per liter of one or more alkali metal sulphates, alkaline earth metal sulphates or a mixture thereof; and 400 to 600 ml water; wherein the solution is free from ascorbate components. 14. The solution of claim 13, further comprising: 1.0 to 4.0 g per liter sodium chloride; and 0.1 to 3.0 g per liter potassium chloride. 15. The solution of claim 13, further comprising a sweetener wherein the sweetener is sucralose. 16. The solution of claim 13, further comprising citric acid. 17. A method of cleansing a colon of a subject comprising administering the solution of claim 13. 18. A method of cleansing a colon of a subject comprising administering the solution of claim 13 in combination with a different colon cleansing solution. 19. A colon cleansing solution, consisting essentially of: 130 to 250 g per liter PEG having an average molecular weight of 2500 to 4500 Da; 15 to 20 g per liter of one or more alkali metal sulphates, alkaline earth metal sulphates or a mixture thereof; 400-600 ml water; optionally 0.5 to 5.0 g per liter sodium chloride; optionally 0.1 to 3.0 g per liter potassium chloride; optionally one or more flavoring agents; and optionally one or more sweeteners; wherein the solution is free from ascorbate components.