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Last Updated: December 17, 2025

Claims for Patent: 11,529,336


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Summary for Patent: 11,529,336
Title:Methods of treating gastrointestinal stromal tumors
Abstract:The present disclosure relates to methods of treating gastrointestinal stromal tumors to a subject in need thereof, comprising administering to the subject a therapeutically effective amount of ripretinib or a pharmaceutically acceptable salt thereof.
Inventor(s):Rodrigo Ruiz Soto, Oliver Rosen, Jama Pitman
Assignee: Deciphera Pharmaceuticals LLC
Application Number:US17/735,678
Patent Claims: 1. A method of treating a patient suffering from a Grade 3 adverse reaction while being administered 150 mg ripretinib daily for treatment of gastrointestinal stromal tumors, comprising: withholding administration of ripretinib for a maximum of 28 days until the adverse reaction resolves to Grade 1 or baseline; then administering to the patient 100 mg daily ripretinib for at least 28 days.

2. The method of claim 1, wherein, if after 28 days of 100 mg daily dosing the adverse reaction in the patient is maintained at Grade 1 or baseline, the method comprises administering 150 mg daily ripretinib to the patient.

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