Claims for Patent: 11,517,609

Summary for Patent: 11,517,609

Title:	Glycopeptide compositions
Abstract:	Solutions comprising a glycopeptide antibiotic, for example Vancomycin, and an amino acid or amino acid derivative such as N-acetyl-Glycine or N-acetyl-D-Alanine are provided. These solutions are stable or stabilized for long-term periods at conditions of normal use and storage, and can be formulated as pharmaceutical solutions for use in subjects. Methods of manufacturing and using these solutions are also provided, as are methods of stabilizing a glycopeptide antibiotic, for example Vancomycin, using amino acids or amino acid derivatives such as N-acetyl-Glycine or N-acetyl-D-Alanine.
Inventor(s):	Ivona Jasprica, Sabina Keser, Katarina Pindric
Assignee:	Hikma Pharmaceuticals USA Inc
Application Number:	US17/860,642
Patent Claims:	1. A method of treating a bacterial infection in a subject in need thereof, comprising administering to the subject an aqueous pharmaceutical composition comprising vancomycin and an N-acetyl-D-amino acid. 2. The method of claim 1, wherein the aqueous pharmaceutical composition is administered parenterally. 3. The method of claim 1, wherein the aqueous pharmaceutical composition comprises vancomycin and an N-acetyl-D-amino acid, wherein the molar ratio of the N-acetyl-D-amino acid to vancomycin is about 0.5:1 to 40:1 and the composition comprises about 0.1-20% w/V vancomycin. 4. The method of claim 3, wherein the aqueous pharmaceutical composition comprises about 0.5% w/V vancomycin. 5. The method of claim 3, wherein the molar ratio of the N-acetyl-D-amino acid to vancomycin in the aqueous pharmaceutical composition is about 1:1 to 30:1. 6. The method of claim 3, wherein the aqueous pharmaceutical composition has a pH of about 4.0-5.5. 7. The method of claim 6, wherein the aqueous pharmaceutical composition has a pH of about 4.5-5.5.