Claims for Patent: 11,511,252

Summary for Patent: 11,511,252

Title:	Conversion of nitrogen dioxide (NO2) to nitric oxide (NO)
Abstract:	A nitric oxide delivery system, which includes a gas bottle having nitrogen dioxide in air, converts nitrogen dioxide to nitric oxide and employs a surface-active material, such as silica gel, coated with an aqueous solution of antioxidant, such as ascorbic acid. A nitric oxide delivery system may be used to generate therapeutic gas including nitric oxide for use in delivering the therapeutic gas to a mammal.
Inventor(s):	David H. Fine, David P. Rounbehler, Gregory Vasquez, Bryan Johnson
Assignee:	Vero Biotech Inc
Application Number:	US16/590,093
Patent Claims:	1. A system, comprising: a pressure regulator configured to diffuse gaseous nitrogen dioxide into an air flow, the pressure regulator including a diffusion cell configured to be connected to a source of the gaseous nitrogen dioxide; and a receptacle fluidically coupled to the pressure regulator, the receptacle including a surface-active material coated with an aqueous solution of an antioxidant configured to convert the gaseous nitrogen dioxide to nitric oxide. 2. A system, comprising: a pressure regulator configured to diffuse gaseous nitrogen dioxide into an air flow; a receptacle fluidically coupled to the pressure regulator, the receptacle including a surface-active material coated with an aqueous solution of an antioxidant configured to convert the gaseous nitrogen dioxide to nitric oxide; and a cartridge disposed downstream of the receptacle and configured to remove nitrogen dioxide from the air flow. 3. The system of claim 2, wherein the cartridge includes activated alumina. 4. The system of claim 2, further comprising: a sample valve coupled to the cartridge and configured to provide samples of the air flow; and a sensor fluidically coupled to the sample valve, the sensor configured to detect nitrogen dioxide present in the samples of the air flow. 5. A system, comprising: a diffusion cell configured to diffuse gaseous nitrogen dioxide into an airflow; a receptacle fluidically coupled to the diffusion cell, the receptacle including a surface-active material wetted with an aqueous solution of an antioxidant configured to convert the gaseous nitrogen dioxide to nitric oxide; and a cartridge downstream of the receptacle, the cartridge configured to remove nitrogen dioxide from the air flow. 6. The system of claim 5, wherein the antioxidant includes ascorbic acid. 7. The system of claim 5, wherein the cartridge includes activated alumina. 8. The system of claim 5, further comprising: a sample valve coupled to the cartridge and configured to provide samples of the air flow; and a sensor fluidically coupled to the sample valve, the sensor configured to detect nitrogen dioxide present in the samples of the air flow.